Results 21 to 30 of about 2,286 (103)

Immunohistochemistry in pre-invasive vulvar lesions: observations, concerns and an algorithmic approach

Journal of Education, Health and Sport
The aim of the study was to investigate the presence of immunohistochemical markers p16, p53 and Ki67 and their diagnostic and prognostic value in women with pre-invasive vulvar lesions such as vulvar high-grade squamous intraepithelial lesions (VHSIL ...
V. Dunaevskaya, V. Med, M. Krotevych
doaj   +1 more source

Exploring the potential prompting role of cervical human papilloma virus detection in vulvar lesions: a cross-sectional study in China

Frontiers in Oncology
IntroductionThe etiology and clinical presentation of vulvar carcinomas, especially vulvar lesions, are not fully understood. Because the vulva and cervix are anatomically connected, human papillomavirus (HPV) is the main cause of cervical lesions. Thus,
Xiaoqing Dang, Quanlong Lu, Jing Li, Ruifang Li, Bo Feng, Chen Wang, Lifang Gao, Ruimei Feng, Zhilian Wang   +8 more
doaj   +1 more source

Long‐term outcome of ablation for anal HSIL: Achieving HSIL‐free status is key—A UK‐based retrospective cohort study

Colorectal Disease, Volume 28, Issue 9, September 2026.
Abstract Introduction Treating anal high‐grade squamous intraepithelial lesions (HSIL) reduces squamous cell carcinoma (SCC) rates in high‐risk groups such as men having sex with men (MSM), especially those living with HIV (LWH). Follow‐up data after HSIL treatment is lacking.
T. Cuming, K. Rozemeijer, E. Farrow, C. Cappello, B. Wait, M. Junejo, J. Bowring, A. N. Rosenthal, O. Richel, M. Nathan, H. J. C. de Vries, J. M. Prins   +11 more
wiley   +1 more source

GATA3 Inhibits the Expression of Viral E6/E7 Genes, and Its Expression Is Compromised During HPV‐Mediated Cervical Carcinogenesis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT High‐risk human papillomaviruses (HPV) are the main etiological agents of cervical cancer. The viral early promoter regulates the expression of E6/E7 oncoproteins, and its transcriptional activity is positively or negatively regulated by host transcription factors (TFs) that are able to bind to the viral long control region (LCR).
Valéria Talpe‐Nunes, Aline Lopes Ribeiro, Rafaella Almeida Nunes, João Simão Sobrinho, Amanda Schiersner Caodaglio, Rossana Veronica Mendonza Lopez, Thais Rocha, Maria Luiza Nogueira Dias Genta, Konstanze Schichl, Ademola Aiyenuro, John Doorbar, Laura Sichero   +11 more
wiley   +1 more source

A 60-Year-Old Woman With Tongue Intractable Erosion

International Dental Journal
Introduction: Paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare autoimmune disease with polymorphic mucocutaneous features and multi-organ involvement.
Juehua Cheng, Zhu Weiwen
doaj   +1 more source

Prognostic impact of anal cancer morphology on survival and local recurrence: A 20‐year regional cohort study

Colorectal Disease, Volume 28, Issue 7, July 2026.
Abstract Aim The relationship between macroscopic tumour morphology and clinical outcomes has previously been demonstrated for malignant melanoma and gastric cancers, but not for anal squamous cell cancer (ASCC). This study investigated the effect of the morphology of ASCC on oncological outcomes.
Alwin Puthiyakunnel Saji, Thomas Rackley, James Horwood, Rachel Hargest   +3 more
wiley   +1 more source

The Role of Enterococcus faecium in the Synergistic Clearance of High‐Risk HPV: A Clinical Study on Cervicovaginal Microbiota Regulation

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Persistent infection with high‐risk human papillomavirus (HR‐HPV) is defined as the principal cause of cervical cancer. Given the important role of cervicovaginal microbiota in HPV acquisition and disease progression, this study aims to evaluate the clinical efficacy of the probiotic Enterococcus faecium (E.
Jun Yang, Mengya Gao, Danfeng Wang, Ziwei Li, Sijing Li, Min Zhou, Li‐Na Hu   +6 more
wiley   +1 more source

An observational study of clinico-pathological characteristics of gynecological tumors and mode of treatment

Asian Journal of Medical Sciences
Background: Gynecological malignancies are a group of various malignancies of the female reproductive system which included cancers of the ovary, cervix, uterus, vulva, vagina, and also gestational trophoblastic neoplasia. Aims and Objectives: The aim
Ashwini R , Ravi N Patil , Shiny Varghese , Nalini Arun Kumar , Sathyavani C   +4 more
doaj   +1 more source

Assessing General Practitioners' Confidence in Undertaking Assessment and Ongoing Management of Patients With Diagnosed, Stable Vulval Lichen Sclerosus (VLS): Laying the Foundation for a Shared‐Care Model

Australasian Journal of Dermatology, Volume 67, Issue 4, Page e239-e247, June 2026.
ABSTRACT Background Vulval Lichen Sclerosus (VLS) is a chronic inflammatory condition requiring lifelong management to prevent severe complications including malignancy. A shared care model between general practitioners (GPs) and public non‐GP specialists (dermatologist or gynaecologist) for patients with stable LS would alleviate the demand on public ...
Arav Kannen, Carolyn Marlow, Suzanne Edwards, Arabella Wallett   +3 more
wiley   +1 more source

Non-invasive diagnosis of vulvar dysplasia using cervical methylation markers—a case control study

BMC Medicine
Background Diagnostic screenings for vulvar squamous intraepithelial lesions (VSIL) are limited and without information on disease trends. A panel of six methylation markers (ASTN1, DLX1, ITGA4, RXFP3, SOX17, ZNF671; GynTect® assay) has shown promise in ...
Sabeth Becker, Lena Dübbel, Dana Behrens, Kristin Knoll, Juliane Hippe, Karin Loser, Eduard Malik, Meike Schild-Suhren   +7 more
doaj   +1 more source