Results 121 to 130 of about 16,664 (252)

GATA3 Inhibits the Expression of Viral E6/E7 Genes, and Its Expression Is Compromised During HPV‐Mediated Cervical Carcinogenesis

open access: yesJournal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT High‐risk human papillomaviruses (HPV) are the main etiological agents of cervical cancer. The viral early promoter regulates the expression of E6/E7 oncoproteins, and its transcriptional activity is positively or negatively regulated by host transcription factors (TFs) that are able to bind to the viral long control region (LCR).
Valéria Talpe‐Nunes   +11 more
wiley   +1 more source

Assessment of Cervicovaginal Smear and HPV DNA Co-Test for Cervical Cancer Screening: Implications for Diagnosis and Follow-Up Strategies

open access: yesDiagnostics
Objective: Cervical cancer is a major cause of cancer-related mortality, necessitating effective screening and diagnostic methods. This study aimed to assess the performance of cervicovaginal smear (CVS) and human papillomavirus (HPV)-DNA co-test.
Neslihan Kaya Terzi, Ozden Yulek
doaj   +1 more source

High-Grade Cervical Intraepithelial Neoplasia: Impact of Colposcopic Lesion Area on Systemic Immune Responses

open access: yes
Priscila Thaís Silva Mantoani,1,2 Douglas Côbo Micheli,2 Millena Prata Jammal,2 Julia Hailer Vieira,3 Márcia Antoniazi Michelin,3 Caroline Gabriela Xavier Ferreira,2 Henrique Nascimento Silva,2 Eddie Fernando Candido Murta,2 Rosekeila Simões Nomelini1,2 ...
Michelin MA   +8 more
core  

Impact of Male Human Papillomavirus (HPV) Vaccination on HPV Infection and HPV‐Related Diseases: A Systematic Review

open access: yesReviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and is responsible for anogenital warts and several cancers. Although the effectiveness of female HPV vaccination has been well established since its introduction in 2006, no systematic review has specifically evaluated the impact of male vaccination ...
Anna Beltrame   +5 more
wiley   +1 more source

Predictive factors for the absence of high‐grade intraepithelial lesions in LLETZ specimens following a prior histological diagnosis

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 7, Page 1240-1246, July 2026.
About 9.4% of patients with biopsy‐proven high‐grade cervical lesions had ultimately no high‐grade lesion (HGIL) in the excision specimen. The probability of the absence of HGIL was significantly increased in patients with a small lesion, with minor changes or normal colposcopy, and in those with normal cytology or minor abnormalities.
Sophia Assirlikian   +10 more
wiley   +1 more source

Chronic ulcerative oesophagitis rich in IgG4‐positive plasma cells – a distinct clinicopathological entity

open access: yesHistopathology, Volume 89, Issue 1, Page 47-57, July 2026.
We report a series of 12 patients (mean age 63 years) with chronic oesophageal ulceration showing morphological features of IgG4‐related inflammatory disease. Most patients underwent several rounds of endoscopy until this association was recognized. The majority of patients went into clinical and histological remission following corticosteroid therapy.
Hanna Henzinger   +5 more
wiley   +1 more source

Cost‐effectiveness analysis of human papillomavirus (HPV) genotyping strategies for management of HPV‐positive women in cervical cancer screening

open access: yesInternational Journal of Cancer, Volume 158, Issue 12, Page 3141-3151, 15 June 2026.
What's new? Persistent infection with high‐risk human papillomavirus (HPV) causes most invasive cervical cancer cases, leading many countries to transition from cytology to primary HPV‐based screening. Despite the benefits, HPV‐based screening may also lead to unnecessary procedures, psychological burden, and strain on healthcare systems.
Kelsi R. Kroon   +2 more
wiley   +1 more source

PD-L1 Expression and Immune Response in Squamous Cervical Lesion and Squamous Cell Carcinoma Cervix

open access: yes, 2022
Aim : To explore the possibility of using anti-PD-L1 immunotherapy in low-grade intraepithelial lesion (LSIL), high-grade intraepithelial lesion (HSIL), and squamous cell carcinoma (SCC) of the cervix.
Syarifuddin Wahid   +5 more
core  

Health care policy trial of primary human papillomavirus–based cervical screening in Denmark: Comparison of three triage algorithms

open access: yesInternational Journal of Cancer, Volume 158, Issue 12, Page 3197-3207, 15 June 2026.
What's new? Primary human papillomavirus (HPV)–based screening has shown superiority to cytology‐based screening in reducing cervical cancer risk in clinical trials. However, the benefit must be balanced with potential overdiagnosis/overtreatment.
Jeppe Bennekou Schroll   +11 more
wiley   +1 more source

Low-grade squamous intraepithelial lesion, cannot exclude high-grade: TBS says Don\u27t Use It! should I really stop it?

open access: yes, 2017
BACKGROUND: The Bethesda System uses a two-tiered approach in the diagnosis of cervical squamous intraepithelial lesions (SILs). Occasionally, Papanicolaou (Pap) tests with evident low-grade SIL (LSIL) also have some features suggestive but not ...
Yee-Chang, Melissa   +7 more
core  

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