Results 81 to 90 of about 598,758 (344)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Formation of an information retrieval system of visual programming scenarios for information modeling software complexes [PDF]

E3S Web of Conferences
This article discusses the process of creating an application based on a specialized database for working with a variety of scripts – visual programming scenarios. The SQL query Language (Structured Query Language) was used as a key tool for implementing
Rybakova Angelina, Piatkov Daniil
doaj   +1 more source

Virtualization in Programmable Data Plane: A Survey and Open Challenges

IEEE Open Journal of the Communications Society, 2020
Programmable data plane (PDP) is an emerging technology for programming packet processing tasks by means of a domain-specific high-level language (e.g., programming protocol-independent packet processor (P4)) and programmable switch chips.
Sol Han, Seokwon Jang, Hongrok Choi, Hochan Lee, Sangheon Pack   +4 more
doaj   +1 more source

Examining the significance of high-level programming features in source code author classification

Journal of Systems and Software, 2008
The use of Source Code Author Profiles (SCAP) represents a new, highly accurate approach to source code authorship identification that is, unlike previous methods, language independent.
Georgia Frantzeskou, Stephen G. MacDonell, E. Stamatatos, S. Gritzalis   +3 more
semanticscholar   +1 more source

Multi-language programming environments for high performance Java computing

, 1999
Recent developments in processor capabilities, software tools, programming languages and programming paradigms have brought about new approaches to high performance computing.
Getov, Vladimir, Mintchev, S., Gray, P., Sunderam, V.S.   +3 more
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

The Preparation of Guidelines for Portable Programming in High-Level Languages [PDF]

The Computer Journal, 1982
Programming even in a folly standardized high-level language requires great care if portable programs are to result. We review two recent attempts at producing guidelines for portable programming in high-level languages. Areas of particular difficulty, software aids to monitor compliance with projected guidelines, the prospects for enhanced portability
openaire   +1 more source