Results 71 to 80 of about 24,769,983 (306)

Meaning and Reference in Programming Languages

Philosophies
This paper provides an analysis of the meaning–reference problem, as traditionally advanced in the philosophy of language, for imperative programming languages.
Nicola Angius
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

CONSIDERATIONS ON OBJECT-ORIENTED PROGRAMMING ENVIRONMENT AUTOCAD DRAWINGS

Journal of Industrial Design and Engineering Graphics, 2015
In recent years, Low Cost CAD systems are widespread in the technical world. Currently, the highest-rated CAD system is AutoCAD due to the fact that in association with AutoLISP programming language covered a broad range of production needs.
PINTILIE Alexandru, AVRAM Elena Rita
doaj  

Domain Specific Abstractions for the Development of Fast-by-Construction Dataflow Codes on FPGAs

Chips
FPGAs are popular in many fields but have yet to gain wide acceptance for accelerating HPC codes. A major cause is that whilst the growth of High-Level Synthesis (HLS), enabling the use of C or C++, has increased accessibility, without widespread ...
Nick Brown
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Qrisp: a framework for compilable high-level programming of gate-based quantum computers

, 2023
The recent advances of quantum computation hardware spark realistic hopes to achieve commercially relevant quantum advantage in less than a decade. While the physics side of quantum computing makes significant progress, the support for high-level quantum
Hauswirth, Manfred, Bock, Sebastian, Seidel, Raphael, Tcholtchev, Nikolay Vassilev   +3 more
core   +1 more source

The Preparation of Guidelines for Portable Programming in High-Level Languages [PDF]

The Computer Journal, 1982
Programming even in a folly standardized high-level language requires great care if portable programs are to result. We review two recent attempts at producing guidelines for portable programming in high-level languages. Areas of particular difficulty, software aids to monitor compliance with projected guidelines, the prospects for enhanced portability
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Formation of an information retrieval system of visual programming scenarios for information modeling software complexes [PDF]

E3S Web of Conferences
This article discusses the process of creating an application based on a specialized database for working with a variety of scripts – visual programming scenarios. The SQL query Language (Structured Query Language) was used as a key tool for implementing
Rybakova Angelina, Piatkov Daniil
doaj   +1 more source