Results 131 to 140 of about 317,795 (294)

Small molecule autoencoders: architecture engineering to optimize latent space utility and sustainability

Journal of Cheminformatics
Autoencoders are frequently used to embed molecules for training of downstream deep learning models. However, evaluation of the chemical information quality in the latent spaces is lacking and the model architectures are often arbitrarily chosen ...
Marie Oestreich, Iva Ewert, Matthias Becker   +2 more
doaj   +1 more source

Don Lindberg, High performance computing and communications, and telemedicine. [PDF]

Inf Serv Use, 2022
Ackerman MJ, Howe SE, Masys DR.
europepmc   +1 more source

Unreliable communication in high-performance distributed multi-agent systems: A ingenious scheme in high computing [PDF]

, 2018
Ali Mustafa, Muhammad Najam-ul-Islam, Salman Ahmed, Muhammad Tufail   +3 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing. [PDF]

Biophys J, 2023
Oikonomou E, Gruber T, Chandra AR, Höller S, Alzheimer C, Wellein G, Huth T.   +6 more
europepmc   +1 more source

Quantum Simulation Using High-Performance Computing

, 2021
Collin Beaudoin, Christian Trefftz, Zachary Kurmas   +2 more
openalex   +1 more source

Resilience and fault tolerance in high-performance computing for numerical weather and climate prediction [PDF]

, 2021
Tommaso Benacchio, Luca Bonaventura, Mirco Altenbernd, Chris D. Cantwell, Peter Düben, Mike Gillard, Luc Giraud, Dominik Göddeke, Erwan Raffin, Keita Teranishi, Nils Wedi   +10 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The COVID-19 High-Performance Computing Consortium. [PDF]

Comput Sci Eng, 2022
Brase J, Campbell N, Helland B, Hoang T, Parashar M, Rosenfield M, Sexton J, Towns J.   +7 more
europepmc   +1 more source

High Performance Computing im Einsatz zur Schwerefeldanalyse mit CHAMP, GRACE und GOCE

, 2004
T. Wittwer
openalex   +2 more sources