Results 101 to 110 of about 15,654,964 (316)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Design of a Maglev Inertial Actuator with High Mass Power Ratio for Lateral Vibration Control of Propulsion Shafting

, 2021
The maglev inertial actuators with high power and mass maybe effective for lateral vibration control of a propulsion shafting. But the mass power ratio of the actuators currently in use is too small to meet the requirements.
Fengyan An, Qianqian Wu, Bilong Liu, Zhihui Liu   +3 more
core   +1 more source

A 3.2 kW Single Stage Narrow Linewidth Fiber Amplifier Emitting at 1050 nm

Micromachines
In this paper, we have demonstrated a narrow linewidth high power fiber laser emitting at a short wavelength of ~1050 nm. The fiber laser is based on a structure of master oscillator power amplification (MOPA) with an optimized fiber Bragg-grating-based ...
Xiaoxi Liu, Xin Tian, Binyu Rao, Baolai Yang, Xiaoming Xi, Zefeng Wang   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ohio Power Siting Board

, 2004
Title from PDF p. [1] (viewed on June 15, 2007).; "Created: 7/6/2004 ..."--Document properties screen.; Brochure. Intended to be printed off on 1 sheet, front and back, and folded in fourths horizontally.; Harvested from the web on 6/15 ...
Ohio Power Siting Board.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Optical fibers for high-power operation

219254Optical fibers have demonstrated, against all early predictions, that their geometry is extremely well-suited for handling high optical powers. However, over the years, many refinements have been done to the basic structure of these waveguides to ...
Limpert, Jens, Jauregui, Cesar
core   +1 more source

Impact of High-Frequency Voltage Distortion Emitted by Large Photovoltaic Power Plant on Medium Voltage Cable Systems

, 2021
Switching processes of voltage source converters can emit significant high-frequency distortions of frequencies between 5 to 20 kHz. Furthermore, the distortions can partly propagate from the place of their origin into a medium voltage system via ...
Hlaváček J., Kněnický M., Procházka R., Šefl O.   +3 more
core   +1 more source

High-Power and High-Efficiency 1.3- $\mu\hbox{m} $ Superluminescent Diode With Flat-Top and Ultrawide Emission Bandwidth

IEEE Photonics Journal, 2015
We report on a flat-top and ultrawide emission bandwidth of 125 nm from InGaAsP/InP multiple quantum-well (MQW) superluminescent diode with antireflection coated and tilted ridge-waveguide device configuration.
M. Z. M. Khan, H. H. Alhashim, T. K. Ng, B. S. Ooi   +3 more
doaj   +1 more source