Results 111 to 120 of about 15,654,964 (316)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Power for Service

open access: yes, 1944
Includes the history of the Puget Sound Power and Light Company power plants and ...
Puget Sound Power and Light Company
core  

Characteristic Analysis of Electromagnetic Force in a High-Power Wireless Power Transfer System

open access: yesEnergies, 2018
In order to explore the influence of the electromagnetic force (EMF) on the coupling mechanism in a high-power wireless power transfer (WPT) system, the characteristics of the EMF are investigated by theoretical calculation and simulation.
Xian Zhang   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Soil microbial community composition and nitrogen enrichment responses to the operation of electric power substation

open access: yesFrontiers in Microbiology
The surge in global energy demand mandates a significant expansion of electric power substations. Nevertheless, the ecological consequences of electric power substation operation, particularly concerning the electromagnetic field, on soil microbial ...
Zhi-Xin Xu   +7 more
doaj   +1 more source

High power evaluation of X-band high power loads

open access: yes, 2010
Several types of X-band high power loads developed for several tens of MW range were designed, fabricated and used for high power tests at X-band facility of KEK. Some of them have been used for many years and few units showed possible deterioration of RF performance.
Matsumoto, Shuji   +4 more
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Fiber MOPAs with high control and high power [PDF]

open access: yes, 2008
High power fiber sources have reached several kilowatts of output power, and are now leading contenders for many applications. Important attractions include control, efficiency, manufacturability, and reliability.
M. S. Z. Abidin   +23 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

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