Results 151 to 160 of about 42,889,069 (366)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Relationship between power system inertia and inter-area mode natural frequency – Analysis and measurements [PDF]
Publisher Copyright: © 2024 The AuthorsDue to the introduction of wind and solar power into power systems, there has been a growing interest in power system inertia during previous years. Also, in several power systems, monitoring of both the frequencies
Kuivaniemi, Mikko +3 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 1957 Progress report issued by the APDA over research and development activities of the Enrico Fermi Atomic Power Plant.
Atomic Power Development Associates
core
Application of 12 MW High-power Soft-starter Equipment in Plateau Refinery
Kongzhi Yu Xinxi Jishu, 2010 According to the starting demand of high-voltage motor with 6 kV/12 MW which applied in a refinery for the energy recovery unit in high-altitude region, a soft-starter is designed for starting two motors, and the system parameters are calculated by the ...
林丽, 张铁军, 张少云, 陈刚
doaj
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Advances in active fibres for high-power and high-brightness fibre sources [PDF]
, 2008 This paper reviews the progress in rare-earth doped fibre technology towards power scaling of high-brightness fibre ...
Jeong, Y. +7 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
EnergiesThe issues of low inertia, overvoltage, and wide-frequency oscillations in high-proportion renewable energy systems have become prominent, posing major challenges to renewable energy integration and threatening grid stability.
Haiyang Liang +8 more
doaj +1 more source