Results 261 to 270 of about 719,896 (409)

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Simple Detection Methods for Antinutritive Factor β-ODAP Present in Lathyrus sativus L. by High Pressure Liquid Chromatography and Thin Layer Chromatography. [PDF]

PLoS One, 2015
Ghosh B, Mitra J, Chakraborty S, Bhattacharyya J, Chakraborty A, Sen SK, Neerathilingam M.   +6 more
europepmc   +1 more source

Detection of genetic mutations in Barrett's esophagus using denaturing high pressure liquid chromatography (DHPLC)

, 2000
Kausilia K. Krishnadathl, Ken Taniguchi, Navtej Buttar, Marlys Anderson, Lori S. Lutzke, Wanguo Liu, Chiping Qian, Ping Yang, Jeremy C. Smith, Kenneth K. Wang   +9 more
openalex   +1 more source

Fc Proteoforms of ACPA IgG Discriminate Autoimmune Responses in Plasma and Synovial Fluid of Rheumatoid Arthritis Patients and Associate with Disease Activity

Advanced Science, EarlyView.
Rheumatoid arthritis is a prototypic autoimmune disease characterized by highly prevalent autoantibodies – anti‐citrullinated protein antibodies (ACPA). A novel nanoHPLC‐MS approach based on the intact Fc/2 subunit identifies hitherto neglected Fc proteoform profiles of IgG (auto)antibodies across different biofluids. The findings demonstrate subclass‐
Constantin Blöchl, Eva Maria Stork, Hans Ulrich Scherer, Rene E. M. Toes, Manfred Wuhrer, Elena Domínguez‐Vega   +5 more
wiley   +1 more source

Nanoodor Particles Deliver Drugs to Central Nervous System via Olfactory Pathway

Advanced Science, EarlyView.
This study have elucidated the brain‐targeted delivery pathways and transport mechanisms of nanoodors by various technical means and found that the olfactory pathway is main one. Nanoodors can rapidly deliver drugs to the central nervous system via olfactory pathway and will hopefully solve the delivery challenges for various types of central nervous ...
Wei Zhang, Xingwang Ji, Qianyanqiu Zhao, Jinyao Qi, Wen Guo, Gaoshuo Zhang, Yujing Guan, Shenglong Li, Yuling Mao   +8 more
wiley   +1 more source

Unveiling Structural Heterogeneity and Evolutionary Adaptations of Heteromultimeric Bacterioferritin Nanocages

Advanced Science, EarlyView.
This study explores the structural heterogeneity and evolutionary adaptations of heteromultimeric bacterioferritins. Hetero‐Bfrs, evolved from either a homo‐Bfr or Ftn by gene duplications, differ from homo‐Bfrs substantially in the mechanisms underpinning iron oxidation and reduction despite high similarity in overall structure.
Yingxi Li, Weiwei Wang, Wei Wang, Xing Zhang, Jinghua Chen, Haichun Gao   +5 more
wiley   +1 more source

Environmental analysis of polar herbicides in complex organic-rich matrices by high performance liquid chromatography atmospheric pressure ionization mass spectrometry (HPLC-API-MS)

, 2003
Luis E. Arroyo‐Mora
openalex   +2 more sources

CircRNA‐mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c‐Myc Axis

Advanced Science, EarlyView.
This study verifies that circRNA‐mTOR exhibits high expression levels in HCC and has a strong correlation with patient prognosis. Mechanistically, circRNA‐mTOR achieves this effect by facilitating the nuclear translocation of RNA‐binding protein (RBP) PSIP1 through specific binding.
Yongchang Tang, Feng Yuan, Mingbo Cao, Yupeng Ren, Yuxuan Li, Gaoyuan Yang, Zhaozhong Zhong, Hao Liang, Zhiyong Xiong, Zhiwei He, Nan Lin, Meihai Deng, Zhicheng Yao   +12 more
wiley   +1 more source

Development of Ultra-High Pressure Capillary Reverse-Phase Liquid Chromatography/Tandem Mass Spectrometry for High-Sensitive and High-Throughput Proteomics

, 2004
Min‐Sik Kim
openalex   +2 more sources

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science, EarlyView.
RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
wiley   +1 more source