Results 41 to 50 of about 576,396 (225)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Rovibrational Analysis of the ν₁, ν₄, ν₁ + ν₄ and ν₁ − ν₄ Bands of ¹³CF₄

Molecules
We present a high-resolution infrared spectroscopic study of four vibrational bands of the 13CF4 isotopologue: the symmetric stretching fundamental ν1, the triply degenerate bending mode ν4, the combination band ν1+ν4, and the hot band ν1−ν4.
Ons Ben Fathallah, Romain Terrier, Laurent Manceron, Cyril Richard, Vincent Boudon   +4 more
doaj   +1 more source

High spectral resolution time-resolved optical spectroscopy of V893 Sco [PDF]

, 2001
We present high resolution time-resolved optical spectra of the high inclination short orbital period dwarf nova V893 Sco. We performed spectral analysis through radial velocity measurements, Doppler mapping, and ratioed Doppler maps.
E. Mason, Horne K., Horne K., Howell S. B., Matsumoto K., Osaki Y., R. E. Mennickent, S. B. Howell, Smak J., Tylenda R., W. Skidmore, Whitehurst R., Wood J. H.   +12 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

High-Resolution Localized NMR Spectroscopy Based on Hadamard-Encoding

Chinese Journal of Magnetic Resonance, 2020
Nuclear magnetic resonance (NMR) is a non-invasive technology which has been widely used in chemical, biological and medical researches. This paper presents a new NMR pulse sequence based on Hadamard spatial encoding and intermolecular single-quantum ...
KE Han-ping, CAI Hong-hao
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

SDSS-V Milky Way Mapper (MWM): ASPCAP Stellar Parameters and Abundances in SDSS-V Data Release 19

The Astronomical Journal
The goal of this paper is to describe the science verification of Milky Way Mapper (MWM) APOGEE Stellar Parameter and Chemical Abundances Pipeline (ASPCAP) data products published in Data Release 19 (DR19) of the fifth phase of the Sloan Digital Sky ...
Szabolcs Mészáros, Paula Jofré, Jennifer A. Johnson, Jonathan C. Bird, Jo Bovy, Andrew R. Casey, Julio Chanamé, Katia Cunha, Nathan De Lee, Peter Frinchaboy, Guillaume Guiglion, Viola Hegedűs, Alex P. Ji, Juna A. Kollmeier, Melissa K. Ness, Jonah Otto, Marc H. Pinsonneault, Alexandre Roman-Lopes, Andrew Saydjari, Amaya Sinha, Ying-Yi Song, Guy S. Stringfellow, Keivan G. Stassun, Jamie Tayar, Andrew Tkachenko, Marica Valentini, Zachary Way, Jörg Weingrill   +27 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Hyperfine interaction in cobalt by high-resolution neutron spectroscopy

, 2018
We have investigated the ferromagnetic phase transition of elemental Co by high-resolution neutron backscattering spectroscopy. We monitored the splitting of the nuclear levels by the hyperfine field at the Co nucleus.
Chatterji, Tapan, Wuttke, Joachim, Zamponi, Michaela   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source