Results 61 to 70 of about 16,837,471 (302)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

High-Resolution Localized NMR Spectroscopy Based on Hadamard-Encoding

Chinese Journal of Magnetic Resonance, 2020
Nuclear magnetic resonance (NMR) is a non-invasive technology which has been widely used in chemical, biological and medical researches. This paper presents a new NMR pulse sequence based on Hadamard spatial encoding and intermolecular single-quantum ...
KE Han-ping, CAI Hong-hao
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Calibrating the Instrumental Drift in MAROON-X Using an Ensemble Analysis

The Astronomical Journal
MAROON-X is a state-of-the-art extreme-precision radial velocity spectrograph deployed on the 8.1 m Gemini-N telescope on Maunakea, Hawai’i. Using a stabilized Fabry–Pérot etalon for wavelength and drift calibration, MAROON-X has achieved a short-term ...
Ritvik Basant, Tanya Das, Jacob L. Bean, Rafael Luque, Andreas Seifahrt, Madison Brady, Nina Brown, Julian Stürmer, David Kasper, Guđmundur Stefánsson   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

High-Resolution Vacuum Ultraviolet Photoelectron Spectroscopy

CHIMIA, 2001
The development of narrow bandwidth tunable laser systems in the vacuum ultraviolet region of the electromagnetic spectrum and of new experimental methods has recently enabled a significant improvement in the resolution that can be achieved by ...
Urs Hollenstein, Bethany Brupbacher-Gatehouse, Gregory M. Greetham, Stefan Willitsch, Patrick Rupper, Andrea Wüest, Marcel Sommavilla, Andreas Osterwalder, Robert Seiler, Frédéric Merkt   +9 more
doaj  

The Limits of Line Broadening: Modeling Stellar Spectra and Formation Temperatures at High Resolution

The Astrophysical Journal
The modeling of stellar spectra is pervasive in astronomy. Conventionally, the shapes of absorption lines are modeled by convolving thermal profiles (computed given some model stellar atmosphere and line list) with broadening kernels intended to account ...
Michael L. Palumbo III
doaj   +1 more source

LiYF4:Ho crystal in a magnetic field: high resolution optical spectroscopy

EPJ Web of Conferences, 2017
Low-temperature high-resolution optical spectra of LiYF4:Ho in an external magnetic field H are presented. A field-dependent transformation of the hyperfine structure of holmium spectral lines is studied for the cases H||c and H┴c.
Boldyrev K.N., Popova M.N.
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

κ Andromedae b Is a Fast Rotator from KPIC High-resolution Spectroscopy

The Astronomical Journal
We used the Keck Planet Imager and Characterizer to obtain high-resolution ( R ∼ 35,000) K -band spectra of κ Andromedae b, a planetary-mass companion orbiting the B9V star, κ Andromedae A. We characterized its spin, radial velocity, and bulk atmospheric
Evan C. Morris, Jason J. Wang, Chih-Chun Hsu, Jean-Baptiste Ruffio, Jerry W. Xuan, Jacques-Robert Delorme, Callie Hood, Marta L. Bryan, Emily C. Martin, Jacklyn Pezzato, Dimitri Mawet, Andrew Skemer, Ashley Baker, Randall Bartos, Benjamin Calvin, Sylvain Cetre, Greg Doppmann, Daniel Echeverri, Luke Finnerty, Michael P. Fitzgerald, Nemanja Jovanovic, Joshua Liberman, Ronald Lopez, Ben Sappey, Tobias Schofield, J. Kent Wallace, Ji Wang   +26 more
doaj   +1 more source