Results 71 to 80 of about 16,837,471 (302)

The impact of interpolation in high-resolution spectroscopy

Astronomy & Astrophysics
Aims. We explore the impact that spectral interpolation introduces in radial velocity (RV) time-series that are extracted using templatebased methods, in particular systematic biases induced in this process. Methods.
Silva A. M., Doshi D., Al Moulla K., Cristo E. A. S., Artigau É., Viana P. T. P., Santos N. C., Martins J. H. C., Marques C. M. J., Sousa S. G., San Nicolas Martinez C., Campante T. L., Cabral A., Cristiani S.   +13 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

PDS 70b Shows Stellar-like Carbon-to-oxygen Ratio

The Astrophysical Journal Letters
The ~5 Myr PDS 70 is the only known system with protoplanets residing in the cavity of the circumstellar disk from which they formed, ideal for studying exoplanet formation and evolution within its natal environment.
Chih-Chun Hsu, Jason J. Wang, Geoffrey A. Blake, Jerry W. Xuan, Yapeng Zhang, Jean-Baptiste Ruffio, Katelyn Horstman, Julianne Cronin, Ben Sappey, Yinzi Xin, Luke Finnerty, Daniel Echeverri, Dimitri Mawet, Nemanja Jovanovic, Clarissa R. Do Ó, Ashley Baker, Randall Bartos, Benjamin Calvin, Sylvain Cetre, Jacques-Robert Delorme, Gregory W. Doppmann, Michael P. Fitzgerald, Joshua Liberman, Ronald A. López, Evan Morris, Jacklyn Pezzato-Rovner, Tobias Schofield, Andrew Skemer, J. Kent Wallace, Ji Wang   +29 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Updated System of S i Levels Using Fourier Transform Infrared Spectroscopy in the Range from 800 to 11,000 cm−1

The Astrophysical Journal Supplement Series
In this study we report on high-precision laboratory measurements of transition wavenumbers for 172 atomic sulfur lines in the infrared region 800–11,000 cm ^−1 using Fourier transform spectroscopy techniques. Our analysis includes 96 lines that have not
S. Civiš, A. Kramida, E. M. Zanozina, J. Kubišta, P. Kubelík, M. Ferus, V. E. Chernov   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Abundance Analysis of the Spectroscopic Binary α Equulei

Galaxies
We present the results of a detailed spectroscopic analysis of the double-lined spectroscopic binary system α Equulei. High-resolution spectra obtained with the SOPHIE spectrograph at various orbital phases were used to disentangle the composite spectra ...
Anna Romanovskaya, Sergey Zvyagintsev
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source