Results 91 to 100 of about 1,540,429 (310)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

THE CHANGE IN DEFORMATION CHARACTERISTICS OF CONCRETE MONOLITHIC HIGH-RISE BUILDINGS

Nauka ta progres transportu, 2009
In the article results of studies of deformation features of concrete on actuate cement for monolithic high-altitude buildings are presented. It is shown that in construction of the high-altitude monolithic buildings in a summer period of a year one ...
V. V. Punahin
doaj  

High-Rise Timber Offices: Main Architectural and Structural Design Parameters

Buildings
High-rise office structures constructed using timber material (with a minimum of eight stories) signify a burgeoning and favorable sector, mainly owing to their ability to offer substantial environmental and economic advantages across their lifespan ...
Hüseyin Emre Ilgın, Özlem Nur Aslantamer   +1 more
doaj   +1 more source

Effect of soft story on structural response of high rise buildings. [PDF]

, 2011
Severe structural damage suffered by several modern buildings during recent earthquakes illustrates the importance of avoiding sudden changes in lateral stiffness and strength.
Abang Ali, Abang Abdullah, Chieng, C. Y., Hejazi, Farzad, Jaafar, Mohd Saleh, Kojouri, Samira Jilani, Noorzaei, Jamaloddin   +5 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

STUDI PERENCANAAN SISTEM DISTRIBUSI AIR BERSIH PADA GEDUNG DITRESKRIMSUS KEPOLISIAN DAERAH JAWA TIMUR [PDF]

, 2023
The plumbing system is an inseparable part of a high-rise building. The plumbing system is used for various purposes such as providing clean water and distributing sewage and waste water.
Adjie, M. Aziz Krisna
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Particulate Matter Emissions from a High-rise Layer House in Iowa [PDF]

, 2009
Particulate matter (PM) in animal feeding operations is a concern for the occupants and the surrounding community. Baseline measurements of the concentration and emission rate of PM are the first step toward assessing the environmental impact of animal ...
Burns, Robert, Li, Hong, Li, Shuhai, Xin, Hongwei, Xin, Hongwei   +4 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Rise of High Throughput

BioTechniques, 2012
The realization that gene, protein, and metabolite space is vast has led to the development of novel high-throughput methodologies aimed directly at interrogating biomolecules and their interactions at previously impossible depths.
doaj   +1 more source