Results 51 to 60 of about 30,129 (215)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Horizontally connected high-rise buildings under earthquake loadings

Ain Shams Engineering Journal, 2019
Responses to lateral loads induced by wind and earthquakes are among the governing factors in the structural design of these structures. In the current trend, adjacent tall buildings are being horizontally connected for different purposes.
Sayed Mahmoud
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The support systems of unique high-rise buildings

MATEC Web of Conferences, 2017
Tall buildings and skyscrapers perceive significant vertical loads and, moreover, have to resist large lateral effects which form strong gusts of wind and seismic events. In the world for the high-rise buildings with the nuclei of the stiffness are using
Shumeyko Victor
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

AERODYNAMICS EVALUATION OF HIGH-RISE BUILDINGS

Journal of Industrial Design and Engineering Graphics
Due to the increasing population density in metropolitan areas, architects have focused on high rise building designs that combine architectural considerations with functional requirements.
Iacob-Liviu SCURTU, Alexandra-Daniela SCURTU   +1 more
doaj   +2 more sources

The adaptability of evolving green high-rise construction: embodied energy dynamics in Australian high-rise buildings

International Journal of Sustainable Energy, 2022
This paper intends to establish what is the most influential embodied energy factor, materials, or construction process for high-rise buildings. This study evaluates the performance of 20 green buildings across Australia.
Koorosh Gharehbaghi, Ken Farnes, Lada Kucharski, Sofia Fragomeni   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Space Efficiency in European High-Rise Timber Buildings

Applied Sciences
As towering wooden edifices (≥8 stories) become a rapidly expanding and promising field, they provide substantial environmental and economic advantages throughout their entire lifespans, leading to their increasing popularity, especially in the European ...
Hüseyin Emre Ilgın, Özlem Nur Aslantamer   +1 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source