Results 51 to 60 of about 16,439,513 (253)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The support systems of unique high-rise buildings

MATEC Web of Conferences, 2017
Tall buildings and skyscrapers perceive significant vertical loads and, moreover, have to resist large lateral effects which form strong gusts of wind and seismic events. In the world for the high-rise buildings with the nuclei of the stiffness are using
Shumeyko Victor
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

AERODYNAMICS EVALUATION OF HIGH-RISE BUILDINGS

Journal of Industrial Design and Engineering Graphics
Due to the increasing population density in metropolitan areas, architects have focused on high rise building designs that combine architectural considerations with functional requirements.
Iacob-Liviu SCURTU, Alexandra-Daniela SCURTU   +1 more
doaj   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Differential axial shortening and its effects in high rise buildings with composite concrete filled tube columns [PDF]

, 2017
Use of concrete filled steel tube columns is becoming increasingly popular in high rise buildings due to their composite action, superior strength, seismic and fire resistance capacities and construction simplicity.
Samarakkody, Dilrukshie I., Dilrukshie I. Samarakkody, David P. Thambiratnam, Chan, Tommy H.T., Moragaspitiya, Praveen H.N., Praveen H.N. Moragaspitiya, Thambiratnam, David P., Tommy H.T. Chan   +7 more
core   +1 more source

Evaluating the impact of neighbouring structures on a high-rise residential block’s performance

, 2021
High-rise buildings typically have a much higher energy demand than low-rise buildings. With the increasing number of high-rise buildings, more research should be carried out to minimise their consumption.
John Kaiser Calautit, Weijie Xu, Carlos Jimenez-Bescos   +2 more
core   +1 more source

Space Efficiency in European High-Rise Timber Buildings

Applied Sciences
As towering wooden edifices (≥8 stories) become a rapidly expanding and promising field, they provide substantial environmental and economic advantages throughout their entire lifespans, leading to their increasing popularity, especially in the European ...
Hüseyin Emre Ilgın, Özlem Nur Aslantamer   +1 more
doaj   +1 more source

The adaptability of evolving green high-rise construction: embodied energy dynamics in Australian high-rise buildings

International Journal of Sustainable Energy, 2022
This paper intends to establish what is the most influential embodied energy factor, materials, or construction process for high-rise buildings. This study evaluates the performance of 20 green buildings across Australia.
Koorosh Gharehbaghi, Ken Farnes, Lada Kucharski, Sofia Fragomeni   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source