Results 71 to 80 of about 30,129 (215)
Understanding Compartmentation Failure for High-Rise Timber Buildings
FireThe traditional concept of compartmentation guaranteed by fire resistance is mainly concerned with the problem of destructive internal spread potential. External convective spread potential pertains to the loss of compartmentation associated with windows
Agustín H. Majdalani +3 more
doaj +1 more source
Optimal Height Of Land Development – An Economic Perspective
Real Estate Management and Valuation, 2015 Sky-scrapers are rising in the panorama of big modern cities more and more often, becoming a symbol of dynamic growth and prestige. High-rise development appears to be an answer to the expanding demand for new residential and commercial space as urban ...
Żelazowski Konrad
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Measuring Airtightness of High-Rise Buildings (Lessons Learned)
BuildingsMeasuring the airtightness of high-rise buildings presents significant challenges due to the effects of wind and thermal lift (stack effect). Small indoor/outdoor temperature differences, combined with the building’s height, can create substantial ...
Stefanie Rolfsmeier +3 more
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Simulation and Optimization Study on the Ventilation Performance of High-Rise Buildings Inspired by the White Termite Mound Chamber Structure. [PDF]
Biomimetics (Basel), 2023 Wei Y, Lin Z, Wang Y, Wang X.
europepmc +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
On the design of high-rise buildings with a specified level of reliability
E3S Web of Conferences, 2018 High-rise buildings have a specificity, which significantly distinguishes them from traditional buildings of high-rise and multi-storey buildings. Steel structures in high-rise buildings are advisable to be used in earthquake-proof regions, since steel ...
Dolganov Andrey, Kagan Pavel
doaj +1 more source