Results 91 to 100 of about 1,333,516 (246)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Subsonic and Transonic Mach Number Tracking Control Strategy Design and Application in an Intermittent Wind Tunnel

IEEE Access
In order to ensure the quality of test data, the Mach number control deviation should be kept within a given range during the continuous-traverse mode force measurement test in a wind tunnel.
Liebo Ma, Cheng Yan, Bo Xiong, Liang Wang   +3 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Three-Dimensional Flutter Numerical Simulation of Wings in Heavy Gas and Transonic Flutter Similarity Law Correction Method

Aerospace
Wind tunnel testing is a crucial method for studying aircraft flutter. Using heavy gas as the wind tunnel medium can mitigate the escalating issue of test models being overweight as advanced aircraft develop.
Zhe Hu, Bo Lu, Yongping Liu, Li Yu, Xiping Kou, Jun Zha   +5 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Investigation on shakedown response-behavior of thawed subgrade soils under long-term traffic loading

Frontiers in Earth Science
The shakedown state of the subgrade is crucial for the sustainable design and long-term stability evaluation of pavement structures. In order to characterize the plastic deformation and shakedown behavior of subgrade soil in seasonal frozen regions ...
Shujian Wang, Xiangyang Li, Yanzheng Ti, Xiaoning Zhang, Tao Yin, Ruibing Wang, Xiufeng Jiang, Zhikai Su, Jianwen Hao   +8 more
doaj   +1 more source

Spin‐Deposited Ruddlesden–Popper Polycrystalline Perovskites for Large‐Area High‐Sensitivity Filterless Narrowband Photodetectors with Ultrafast Response Speed [PDF]

Lihua Lu, Ziang Wan, Zhongli Guo, Hongqiang Luo, Yuanyuan Tian, Sijie Jiang, Yikai Yun, Hailong Hu, Sijia Zhou, Mengyu Chen, Cheng Li, Rong Zhang   +11 more
openalex   +1 more source

Research and development of high-speed on-chip photodetectors based on A^IIIB^V heterostructures [PDF]

, 2019
И. В. Писаренко, E. A. Ryndin
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source