Results 121 to 130 of about 41,974,173 (304)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

High speed rail: benefits that add up [PDF]

, 2012
This report argues that Australian could gain $48 billion of benefits from adopting high speed rail. High speed rail (“HSR”) now exists on every continent except for Australia and Antarctica.
Naomi Edwards
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Research on Virtual Calibration Method for Strain Gauge Balance Based on Non-Linear FEA

Measurement Science Review
This study proposes a method for predicting the static calibration (SC) matrix of strain gauge balances during the development stage. Non-linear finite element analysis (FEA) is employed to simulate the complex deformation behavior of a six-component ...
Wang Chao, Ma Tao, Xu Zhiwei, Xiang Guangwei, Zhang Huangwei, Mi Peng   +5 more
doaj   +1 more source

Geometrically Nonlinear Static Analysis of High-Aspect-Ratio Truss-Braced Wing

Engineering Proceedings
Truss-braced wings (TBWs) feature higher aspect ratios with a lighter weight and lower bending moment than conventional wings. These wings show significant potential for performance improvements in terms of fuel efficiency.
Yanxin Huang, Jinchi Chen, Qingyuan Ma
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Calculation and uncertainty analysis method for airfoil drag coefficient considering compressibility

AIP Advances
In order to meet the need of evaluating the effectiveness of airfoil drag reduction design, the calculation and uncertainty analysis method for airfoil drag coefficient considering compressibility is studied.
Yufeng Du, Qiuting Guo, Lulu Wang, Jilong Zhu, Neng Xiong   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Evaluation of balance measurement uncertainty based on standard error of calibration coefficients

Kongqi donglixue xuebao
The measurement uncertainty of strain gauge balance is one of the important sources of uncertainty in aircraft wind tunnel test data. The conventional methodology obtains the balance calibration formula through the comprehensive loading residual method ...
Chao Wang, Bin Xie, Qiang Li, Renhui Tian, Weiqiang Zhao   +4 more
doaj   +1 more source

HIGH-SPEED RAIL IN THE MIDWEST UNITED STATES: POTENTIAL FOR SUCCESS [PDF]

This paper assesses the potential for successful provision of high-speed rail (HSR) in the Midwestern United States, and concludes by identifying major lessons that other states and regions in the United States interested in developing HSR can draw from ...
Shishir MATHUR, Srikalyani SRINIVASAN
core