Results 181 to 190 of about 36,236,534 (364)
A Unified Mathematical Model for High Speed Hybrid (Air and Water-borne) Vehicles. [PDF]
, 2007 During the last two decades, the interest in civil and military high speed marine vehicles has lead to several new configurations. Some of them exploit a combination of aerodynamic and hydrodynamic forces to sustain part of the weight of the craft ...
Patel, Minoo H. +2 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
THE HIGH-SPEED RAIL DEVELOPMENT IN THE NORTHEAST MEGAREGION OF THE UNITED STATES: A CONCEPTUAL ANALYSIS [PDF]
This paper examines the high-speed rail (HSR) development issues in the Northeast Megaregion of the United States (U.S.). Due to chronic underinvestment and a myriad of other factors, the only operational HSR in the U.S., i.e., Amtrak’s Acela Express, is
Xueming CHEN
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Research related to vibrations from high speed railway traffic
, 2008 We discuss here recent results from several research programmes related to dynamic aspects and vibrations induced by high speed railway traffic, developed at the computational mechanics group, within the “Escuela de Ingenieros de Caminos” of the ...
Gabaldón Castillo, Felipe +1 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
High-speed railway developments and corporate location decisions. The role of accessibility [PDF]
Accessibility is a major factor that determines the effects of transport infrastructure developments on corporate location decisions. High-speed railways have an impact on accessibility by reducing travel times and increasing comfort.
Jasper Willigers
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