Results 181 to 190 of about 9,540 (245)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Integration of the D‐Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability

Advanced Science, EarlyView.
Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu, Tao Zhu, Ziru Zhou, Wei Chen, Chao He, Xinkai Zhou, Xin Wang, Chuanye Chen, Bo Yang, Jiaqi Wei, Caixia Lan, Mengmeng Liu, Handong Su, Qiang Li, Xin Hu, Siteng Bi, Weizhi Ouyang, Xingwang Li, Hailiang Mao, Masahiro Kishi, Kerstin Kaufmann, Alisdair R. Fernie, Dijun Chen, Wenhao Yan   +23 more
wiley   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

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Rare earth element separations by high-speed counter-current chromatography

Journal of Chromatography A, 2022
Following the initial development of High-Speed Counter-Current Chromatography (HSCCC) in the 1960s, several studies have explored its applicability in the separation of rare earth elements (REEs). More recently, however, HSCCC publications have transitioned towards the separation of natural products or pharmaceuticals, leaving the application for REEs
Mateusz Dembowski, John E. Rowley, Kevin Boland, Janelle Droessler, David A. Hathcoat, Alexandria Marchi, George S. Goff, Iain May   +7 more
openaire   +2 more sources

High-speed counter-current chromatography of apple procyanidins

Journal of Chromatography A, 2000
Apple procyanidins were separated by high-speed counter-current chromatography using a type-J multilayer coil planet centrifuge. Several two-phase solvent systems with a wide range of hydrophobicities from a non-polar hexane system to polar n-butanol systems were evaluated their performance in terms of the partition coefficient and the retention of the
Y, Shibusawa, A, Yanagida, A, Ito, K, Ichihashi, H, Shindo, Y, Ito   +5 more
openaire   +2 more sources

Sample capacity in preparative high-speed counter-current chromatography

Journal of Chromatography A, 2007
High-speed counter-current chromatography (HSCCC) is a versatile technique in preparative separation and purification of pure compounds from complex matrices. As a preparative chromatography, there is a need to maximize the column production. Based on the plate theory of Van Deemter, the effect of the sample load on the separation was investigated in a
Zhao, Chun-Xia, He, Chao-Hong
openaire   +5 more sources

Axial dispersion coefficient in high-speed counter-current chromatography

Journal of Chromatography A, 2009
Experimental measurements of axial dispersion coefficients in high-speed counter-current chromatography have been carried out in the single-phase and two-phase modes. Axial dispersion coefficients were calculated from the residence time distribution curve (or the elution profile).
Zhao, Chun-Xia, Xua, Ya-Lan, He, Chao-Hong   +2 more
openaire   +4 more sources

Isolation of bacitracins A and F by high-speed counter-current chromatography

Journal of Chromatography A, 1991
The major components of bacitracin were separated and purified using high-speed counter-current chromatography (HSCCC). A systematic search for optimum two-phase solvent systems resulted in two systems: chloroform-ethanol-methanol-water (5:3:3:4) and chloroform-ethanol-water (5:4:3).
K, Harada, Y, Ikai, Y, Yamazaki, H, Oka, M, Suzuki, H, Nakazawa, Y, Ito   +6 more
openaire   +2 more sources

Separation and purification of peptides by high-speed counter-current chromatography

Journal of Chromatography A, 1995
Preparative separations of peptides have been accomplished using high-speed counter-current chromatography. This has been made possible by the use of a particular solvent system that does not exhibit solvent carryover at high speed flow and centrifugation conditions.
M, Knight, M O, Fagarasan, K, Takahashi, A Z, Geblaoui, Y, Ma, Y, Ito   +5 more
openaire   +2 more sources