Results 131 to 140 of about 17,316,343 (262)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Support-Based Approach to Flight and Vertical Locomotion in Apis mellifera Revealed by High-Speed Imaging

Fluids
Honeybee (Apis mellifera) flight and vertical locomotion were investigated using high-speed imaging and schlieren flow visualization. Free-flight recordings were analyzed to extract wingbeat frequency, projected stroke amplitude, wingtip trajectories ...
Emilia Georgiana Prisăcariu, Oana Dumitrescu   +1 more
doaj   +1 more source

Clinical characterization of respiratory large droplet production during common airway procedures using high-speed imaging. [PDF]

Sci Rep, 2021
Mueller SK, Veltrup R, Jakubaß B, Kniesburges S, Huebner MJ, Kempfle JS, Dittrich S, Iro H, Döllinger M.   +8 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Droplet Volume Median Diameter Estimation from Near-Nozzle Liquid-Sheet Morphological and Textural Features in Flat-Fan Sprays

Agronomy
The near-nozzle liquid sheet is a precursor to droplet formation, yet the quantitative relationship between its visual signatures and downstream droplet volume median diameter (Dv50) remains insufficiently characterized.
Hang Shi, Miao Wu, Nuo Li, Hao Sun, Yafei Wang, Guobin Wang, Changxi Liu, Jun Hu   +7 more
doaj   +1 more source

Towards high-speed computational scattered light imaging by introducing compressed sensing for optimized illumination

We propose the application of Compressed Sensing to Computational Scattered Light Imaging to decrease measurement time and data storage. Computational Scattered Light Imaging (ComSLI) determines three-dimensional fiber orientations and crossings in ...
Van Staalduine, Simon (author), Amunts, Katrin (author), auf der Heiden, F.K. (author), Axer, Markus (author), Münzer, Oliver (author), Menzel, Miriam (author)   +5 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Megapixel time-gated SPAD image sensor for scientific imaging applications

We present a 1 megapixel single-photon avalanche diode (SPAD) camera featuring 3.8 ns time gating and 24 kfps frame rate for 1-bit images, fabricated in 180 nm CMOS image sensor technology.
Ulku, Arin Can, Whitelaw, Jamie, Turpin, Alex, Insall, Robert, Bruschini, Claudio, Zickus, Vytautas, Morimoto, Kazuhiro, Machesky, Laura, Fatima, Areeba, Antolovic, Ivan Michel M., Kapitany, Valentin, Faccio, Daniele, Ardelean, Andrei, Wu, Ming-Lo, Charbon, Edoardo   +14 more
core  

Label-free cell-cycle analysis by high-throughput quantitative phase time-stretch imaging flow cytometry

, 2018
Biophysical properties of cells could complement and correlate biochemical markers to characterize a multitude of cellular states. Changes in cell size, dry mass and subcellular morphology, for instance, are relevant to cell-cycle progression which is ...
Wong, KKY, Lee, KCM, Mok, ATY, Tsia, KKM
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source