Results 151 to 160 of about 17,316,343 (262)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Features of cavitation flow around a scaledddown model of guide vanes of a Francis turbine
Известия Томского политехнического университета: Инжиниринг георесурсов, 2019 Processes accompanying gas-vapor cavitation and nonstationarities of various origins are widely acknowledged to be the major causes of impairment of hydrotechnical equipment performance.
Mikhail Timoshevskiy +6 more
doaj
High-speed imaging of ESCRT recruitment and dynamics during HIV virus like particle budding. [PDF]
PLoS One, 2020 Gupta S, Bromley J, Saffarian S.
europepmc +1 more source
High Speed Communication Techniques
, 2019 This thesis deals with High Speed networks and their relevance in society. It explains the its technologies, performance and applications.The emergence of new high-speed networks challenges our view of distributed networking to great extent. The increase
Osadebamwen, Eghosa Okeoghene
core
Calibration of Aluminum Sheets by High-Speed Hydroforming
A new, robust production system for tubular and sheet-based workpieces is presented. It combines the methodologies of high-speed forming with conventional hydroforming and is based on components and drive technology that can be easy controlled by the ...
Wieseler, T. +4 more
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
, 2009 This paper presents an integrated portable measurement system for the study of high speed and high temperature unsteady plasma flows such as those found in the vicinity of high current switching arcs.
Sharkh, S.M. +3 more
core +1 more source