Results 111 to 120 of about 696,698 (308)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Parallelized compressive spontaneous Raman imaging via SPAD arrays (Conference Presentation)
Compressive Raman imaging has emerged as a promising technique to speed up chemical imaging by compressing the data during acquisition. Yet, current scanning imaging speed is fundamentally limited by the sensors pixel dwell times of at best 1 µs.
Gentner, Clémence +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Simulating Speed in Language: Contributions from vision, audition and action
, 2015 Embodied theories propose that understanding meaning in language requires the mental simulation of entities being referred to. These mental simulations would make use of the same modality-specific systems involved in perceiving and acting upon such ...
Speed, LJ
core
, 2018 Biophysical properties of cells could complement and correlate biochemical markers to characterize a multitude of cellular states. Changes in cell size, dry mass and subcellular morphology, for instance, are relevant to cell-cycle progression which is ...
Wong, KKY, Lee, KCM, Mok, ATY, Tsia, KKM
core +1 more source
Virtual and Physical PrototypingTo address safety and labour-intensive challenges in laser powder bed fusion, a novel Metal Additive Manufacturing using Powder Sheets (MAPS) method is employed.
Wenyou Zhang +15 more
doaj +1 more source
High-speed imaging reveals the bimodal nature of dense core vesicle exocytosis. [PDF]
Proc Natl Acad Sci U S A, 2023 Zhang P, Rumschitzki D, Edwards RH.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
High-throughput single-cell imaging by multi-modal FACED microscopy
, 2019 We demonstrate a high-throughput multimodal imaging flow cytometry platform based on a recently developed all-optical laser scanning technique dubbed free-space angular chirped enhanced delay (FACED).
Wong, KKY +4 more
core