Results 101 to 110 of about 867,475 (306)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
The ballast pick-up problem. A theoretical approach and two experimental campaigns [PDF]
, 2011 The aim of this contribution is to present a theoretical approach and two experimental campaigns (on wind tunnel and on the track) concerning the research work about the ballast train-induced-wind erosion (BTIWE) phenomenon.
Alonso Gimeno, Diana +8 more
core
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Design and analysis of biomimetic nested lattice structures based on additive manufacturing
Alexandria Engineering JournalThere are various hierarchical structures in nature, such as the double-layer wings of a dragonfly, which possess enhanced mechanical properties while also being lightweight.
Dongming Li +3 more
doaj +1 more source
Train Scheduling and Rolling Stock Assignment in High Speed Trains
Procedia - Social and Behavioral Sciences, 2014 The Train Timetabling Problem (TTP) has been widely studied for freight and passenger rail systems. A lesser effort has been devoted to the study of high-speed rail systems. A modeling issue that has to be addressed is to model departure time choice of passengers on railway services.
Espinosa Aranda, José Luis +3 more
openaire +2 more sources
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
The high-speed train and its spatial effects [PDF]
Investigaciones Regionales - Journal of Regional Research, 2004 This paper analyses the high-speed train from a spatial point of view. The basic characteristics of this transportation mode,the evolution of high-speed networks in several countries and the building of a trans-European high-speed railway network are ...
Javier Gutiérrez Puebla
doaj
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Innovation and Development of High-speed Railway in China
机车电传动, 2010 This paper introduced the construction plan of China’s high-speed railway and described nine key technologies and ten supporting techniques of high speed train. The basic model of China high speed train has been given.
张卫华, 王伯铭
doaj
, 2016 To attain seamless handover and reduce the han- dover failure probability for high-speed railway (HSR) com- munication systems, this paper proposes a remote antenna unit (RAU) selection assisted handover scheme where two antennas are installed on high ...
Fan, Pingyi +4 more
core +1 more source