Results 81 to 90 of about 180,713 (315)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

High speed train communications systems using free space optics

, 2010
In this work, we propose a broad-band free space optical (FSO) wireless communications system for high-speed trains. The system consists of optical transceivers positioned outside the train and along the railway track.
Ghassemlooy, Zabih, Paudel, Rupak, Rajbhandari, Sujan, Le Minh, Hoa, Iaz, M.   +4 more
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Analysis of flow and aerodynamic noise behaviour of a simplified high-speed train bogie inside the bogie cavity

, 2014
Aerodynamic noise becomes significant for high-speed trains but its prediction in an industrial context is difficult. The flow and aerodynamic noise behaviour of a simplified high-speed train bogie at scale 1:10 are studied here through numerical ...
Zhu, Jianyue, Hu, Zhiwei, Thompson, David J.   +2 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Dynamic Control of High-speed Train Following Operation

Promet (Zagreb), 2014
Both safety and efficiency should be considered in high-speed train following control. The real-time calculation of dynamic safety following distance is used by the following train to understand the quality of its own following behavior.
Deng Pan, Yingping Zheng
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Research on the Train Surface Pressure Characteristics in Passing through Tunnels at Speeds of 400 km/h and above

Chengshi guidao jiaotong yanjiu
［Objective］ In order to ensure the running safety of trains with a speed of 400 km/h and above when passing through tunnels and improve the passenger ride comfort, it is necessary to adopt the numerical simulation method to study the characteristics of ...
HU Yingcan, DU Jian, CAI Junshuang, HU Chong, LU Yibin   +4 more
doaj   +1 more source

High-speed rail’s impact on the location of office employment within the Dutch Randstad area [PDF]

With the upcoming implementation of high-speed railway infrastructure in the Netherlands, interest has arisen in the spatial-economic effects this might have.
Bert Van Wee, Han Floor, Jasper Willigers   +2 more
core  

aircraft and high-speed train substitution

, 2010
This book section is from A Dictionary of Transport Analysis: This concise and clearly focused Dictionary, with contributions by the leading authorities in their fields, brings order and clarity to a topic that can suffer from confusion over terminology and concepts.
openaire   +1 more source