Results 61 to 70 of about 180,713 (315)
Investigation of aerodynamic performance of high-speed train by detached eddy simulation
, 2012 The detached eddy simulation (DES) is employed to study the flows around the high speed train at speed of 500km/h. Its object is to evaluate the aerodynamic performance. As we know, for high speed trains at speeds bigger than 250 km/h, most (about 75-80%)
Yang GW(杨国伟) +2 more
core +1 more source
Lambertian source modelling of free space optical ground-to-train communications [PDF]
, 2012 There is a increasing demand for high speed data services while travelling on trains and other means of public transportation. Hence, an alternative technology to radio frequency (RF) communications called free space optics (FSO) could be used to provide
Ghassemlooy, Zabih +9 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Design and strengthening of dual bio-inspired lattice structures based on additive manufacturing
Alexandria Engineering JournalLattice structures are widely studied and applied due to their excellent energy absorption capabilities. This study drew inspiration from natural structures and started from the structural form.
Tongyuan Sun +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Parametric design and optimization of high speed train nose [PDF]
, 2016 Aiming at shortening the design period and improve the design efficiency of the nose shape of high speed trains, a parametric shape optimization method is developed for the design of the nose shape has been proposed in the present paper based on the VMF ...
孙振旭 +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Development of Domestic High Speed Train Bogie Steel
Teshugang, 2022 The material changes and property requirements of domestic railway bogie steel from 1950's ~ 20109 s are summarized. At the same time, the chemical composition design, strength grade and atmospheric corrosion resistance mechanism of steel for cast steel ...
张瑞琦 +5 more
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Three-dimensional aerodynamic optimization design of high-speed train nose based on GA-GRNN
, 2012 With the speed upgrade of the high-speed train, the aerodynamic drag becomes one of the key factors to restrain the train speed and energy saving.
Yao SB(姚拴宝) +2 more
core +1 more source