Results 41 to 50 of about 16,059,891 (259)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Mechanical properties and energy absorption of CoCrNi functionally graded TPMS cellular structures
Journal of Materials Research and TechnologyFunctionally gradient triply periodic minimal surface (TPMS) structures are found widespread applications in fields such as aerospace and defense engineering, owing to flexible modulation of lightweight and energy-absorbing properties.
Zhaoyi Wang +6 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Fatigue performance of bogie weld roots: Failure analysis and numerical modeling
Results in EngineeringIn engineering practice, accurately identifying root failure mechanisms and quantitatively evaluating fatigue performance improvements in the absence of load spectrum conditions remains a challenge.
Shaoze Zhou +3 more
doaj +1 more source
Improvement of Accuracy in Damage Localization Using Frequency Slice Wavelet Transform
Shock and Vibration, 2012 Damage localization is a primary objective of damage identification. This paper presents damage localization in beam structure using impact-induced Lamb wave and Frequency Slice Wavelet Transform (FSWT).
Xinglong Liu +2 more
doaj +1 more source
, 2012 Characteristic of cross wind field, such as uniform wind and lower atmospheric boundary layer wind, have directly influence on the operation safety of high-speed train which running in cross wind environment.
Fang Y, Yang GW(杨国伟), Xi YH, Mao J
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Materials & DesignNoise and impact hazards are ubiquitous in engineering applications, creating an urgent demand for multifunctional materials capable of absorbing both acoustic and stress wave energy.
Shiyi Wang +4 more
doaj +1 more source
Considerations on Active Control of Crosswind Stability of Railway Vehicles [PDF]
, 2013 The DLR research project Next Generation Train deals with concepts, methods and technologies for a very high-speed train in double deck configuration and light-weight design.
Kurzeck, Bernhard +3 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source