Results 41 to 50 of about 104,541 (265)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Comparative study on dynamic mechanical properties of additive manufacturing high strength steel and wrought high strength steel under high strain rate

Journal of Materials Research and Technology
Additive manufacturing high-strength steel has a unique manufacturing process and has broad application prospects in military equipment, aerospace, and other fields, but it is often threatened by dynamic loads such as explosion and high-speed impact ...
Zheng-qing Zhou, Pei-ze Zhang, Yu-long Zhang, Bin Hu, Xing-bo Xie, Gui-li Yang, Ming-shou Zhong, Jia Liu, Zhi-ming Bai   +8 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Mechanical properties of high-strength HTRB600 steel bars under high temperature

工程科学学报, 2017
Tensile testing of HTRB600 steel bars under high temperature was conducted to determine the mechanical properties of the steel under high temperature. The elastic modulus, proportional limit, yield strength, ultimate strength, and stress-strain curves of
GONG Wei, HU Ke-xu, WANG Yi-di
doaj   +1 more source

The effects of steel fiber waste tyre on properties of high strength fly ash concrete [PDF]

MATEC Web of Conferences, 2019
The utilization of steel fiber from waste tyres can be an alternative to reduce waste tyres due to the increase of tyre production in Indonesia annually. Steel fiber from waste tyre can be added to concrete mix to improve the concrete properties. In this
Fauzan, Kurniawan Rudy, Lovina A. N Claudia, Fitrah N Oscar, Basenda T Putri   +4 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Experimental Study and Prediction Model of Low Temperature Mechanical Properties of High-Strength Steel

Shanghai Jiaotong Daxue xuebao
The application of high-strength steel in extremely cold polar regions can reduce steel consumption and save the cost of fabrication, transportation, and installation of steel structures in the harsh low-temperature environment.
CAI Ao, CHEN Mantai, ZUO Wenkang, DUAN Liping, ZHAO Jincheng
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Influence of microstructure on fatigue property of ultra high-strength steels

Fracture and Structural Integrity, 2019
Ultra-high-strength steels (with tensile strength higher than 980 MPa) are widely used in automobile manufacturing owing to their lightweight that contributes to fuel efficiency.
Kanji OKUDA, Kazuhiro OGAWA, Yuji ICHIKAWA, Tsuyoshi SHIOZAKI, Naoki YAMAGUCHI   +4 more
doaj   +3 more sources

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source