Results 121 to 130 of about 696,846 (316)

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers   +7 more
wiley   +1 more source

Studies and modelling of high temperature diffusion processes in selected high performance structural coating systems

open access: yes
The central theme of the work undertaken in this thesis involved modelling of diffusion – numerical and microstructural – occurring during high temperature exposure of selected materials and coatings. The materials and coatings and their high temperature
Ahmad, Haifa
core  

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar   +3 more
wiley   +1 more source

Developments in advanced high temperature disc and blade materials for aero-engine gas turbine applications

open access: yes, 2012
The research carried out as part of this EngD is aimed at understanding the high temperature materials used in modern gas turbine applications and providing QinetiQ with the information required to assess component performance in new propulsion systems ...
Everitt, S., Everitt, Stewart
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

High temperature superconducting oxides.

open access: yesNihon Kessho Gakkaishi, 1987
Brief introduction to the high temperature superconducting oxides which have been discovered is presented. And also possible mechanisms for the superconductivity are surveyed.
openaire   +2 more sources

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

MCrAlY Coating for High Temperature Oxidation Resistance of Engine Blade

open access: yesMedžiagotyra
Engines have always been an important part of the development of the industrial field. With the continuous innovation of technology the requirements for the use of engines have become more stringent.
Yan LI, Yue HU, Bo YU
doaj   +1 more source

Oxidation resistance of carbides in chlorine-containing atmospheres

open access: yes, 2022
S.307-320High temperature oxidation resistance of various carbides was investigated in air and in chlorine containing environments. Thermogravimetric oxidation tests were performed on fine powders of Cr3C2, TiC, TiCN, and WC in N-2-20%O-2 and in N-2-20%O-
Berger, L.M.   +4 more
core  

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