Results 171 to 180 of about 149,249 (267)

Identification and functional analysis of novel precursor genes in cyclic peptide biosynthesis in Pseudostellaria heterophylla. [PDF]

BMC Plant Biol
Xu J, Zheng W, Ou X, He H, Yang C, Guo L, Xiao C, Jiang W, Shu G, Zhou T.   +9 more
europepmc   +1 more source

HLA‐DQA1*01:02 is associated with antibody multi‐reactivity with citrulline‐containing type II collagen epitopes while HLA‐DRB1*04:01 is associated with more private antibody reactivity with citrulline‐containing IgG epitopes in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Anti‐citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross‐reactive binding to many antigens containing short motifs, or private with little cross‐reactivity. Also, ACPA reactivity patterns differ among RA patients, including for motif‐containing epitopes in important self‐antigens like collagen ...
S. Janna Bashar, Courtney B. Myhr, Adam H. Titi, Zihao Zheng, Miriam A. Shelef   +4 more
wiley   +1 more source

Automated environmental metagenomics using Oxford nanopore sequencing. [PDF]

BMC Genomics
Child HT, Wierzbicki L, Joslin GR, Roper K, Haxhiraj Q, Tennant RK.   +5 more
europepmc   +1 more source

Enhanced Production of Astaxanthin and Zeaxanthin by Paracoccus Sp. LL1 Through Random Mutagenesis

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Astaxanthin, a high‐value carotenoid with potent antioxidant and anti‐inflammatory activities, is increasingly in demand in various industries. This study reports the successful enhancement of astaxanthin and zeaxanthin production in Paracoccus sp. LL1 through random mutagenesis using ethyl methanesulfonate (EMS).
Anoth Maharjan, Beom Soo Kim
wiley   +1 more source

Profiling RNA G-Quadruplexes In vivo. [PDF]

Curr Protoc
Yang B, Ding Y, Zhang Y.
europepmc   +1 more source

Zebrafish: A Versatile and Powerful Model for Biomedical Research

BioEssays, EarlyView.
Zebrafish are vital for advancing precision medicine, offering a genetically tractable and optically transparent vertebrate model with strong genetic homology to humans. They enable rapid and cost‐effective disease modeling and drug discovery, accelerating insights into cardiovascular, neurological, metabolic, and oncological disorders through gene ...
Sundus Siddiqui, Hiba Siddiqui, Emna Riguene, Michail Nomikos   +3 more
wiley   +1 more source

cONcat: Computational reconstruction of concatenated fragments from long Oxford Nanopore reads. [PDF]

PLoS One
Petri AJ, Thi-Huyen Nguyen M, Rajwar A, Benson E, Sahlin K.   +4 more
europepmc   +1 more source

Comprehensive Mapping of Functional Enhancers in Chinese Hamster Ovary Cells

Biotechnology and Bioengineering, EarlyView.
In this study, the authors identified regions with enhancer activity in the CHO cell genome using genome‐wide and targeted STARR‐seq. The analysis revealed thousands of newly identified enhancer sequences, where some of the most active sequences could drive transgene expression at levels similar to or higher than strong viral enhancers.
María Santos, Yusuf B. Johari, Laura Biggins, Natalie C. Elliott, Stefan Schoenfelder, Mounika Boddireddy, Daniel K. Fabian, Michael Anbar, Peter M. O'Callaghan, Peter J. Rugg‐Gunn   +9 more
wiley   +1 more source

Next-Generation Sequencing: A Review of Its Transformative Impact on Cancer Diagnosis, Treatment, and Resistance Management. [PDF]

Diagnostics (Basel)
Isaic A, Motofelea N, Hoinoiu T, Motofelea AC, Leancu IC, Stan E, Gheorghe SR, Dutu AG, Crintea A.   +8 more
europepmc   +1 more source

Enhanced deoxyviolacein bioproduction via enzyme condensation with a yeast glycolytic enzyme‐derived peptide tag

Biotechnology Progress, EarlyView.
Fusion of a 27‐amino‐acid peptide tag derived from a glycolytic enzyme enabled artificial assembly formation of the two violacein biosynthetic enzymes, VioE and VioC. This assembly resulted in enhanced biosynthesis of deoxyviolacein. Abstract In microbial production, regulating endogenous and exogenous synthetic pathways is essential.
Rioko Ito, Sayoko Ito‐Harashima, Naoko Segawa, Natsuko Miura, Michihiko Kataoka   +4 more
wiley   +1 more source