Results 201 to 210 of about 149,249 (267)

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Decoding gene essentiality in <i>Streptococcus suis</i> using Tn-seq and genome-scale metabolic modeling. [PDF]

Microbiol Spectr
Hong Y.
europepmc   +1 more source

Methodological Comparison of Short-Read and Long-Read Sequencing Methods on Colorectal Cancer Samples. [PDF]

Int J Mol Sci
Szakállas N, Kalmár A, Rada KR, Kucarov M, Linkner TR, Barták BK, Takács I, Molnár B.   +7 more
europepmc   +1 more source

Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming

Food Frontiers, EarlyView.
This study unveils how ASIV reverses diabetic nephropathy by restoring Gna13‐K363 acetylation and reprogramming purine metabolism. Using spatial metabolomics and acetylproteomics, we identified zonation‐specific purine dysregulation in diabetic kidneys, with ASIV normalizing metabolite distribution (hypoxanthine, cAMP, guanine) and targeting Gna13 ...
Shi Qiu, Sifan Guo, Dandan Xie, Zhibo Wang, Ying Cai, Xian Wang, Qiang Yang, Chunsheng Lin, Hong Yao, Qiqi Zhao, Yu Guan, Songqi Tang, Yiqiang Xie, Aihua Zhang   +13 more
wiley   +1 more source

Report of longan witches' broom-associated virus in lychee imported from China. [PDF]

Microbiol Resour Announc
Belete MT, Park E, Kim Y, Yun S, Lee J-H, Lee D-S, Lim S, Lee S-J.   +7 more
europepmc   +1 more source

Synthetic Kefir Based on Fermentation of Natural Kefir and Koumiss Core Microbial Species Reveals Microbial Interactions and Gene Exchanges in Natural Kefir

Food Frontiers, EarlyView.
ABSTRACT Kefir and koumiss are both traditional alcoholic fermented milk drinks made from the fermentation of various probiotics and yeasts. The complex microbial composition of kefir and koumiss has hindered the expansion of their consumption in global markets.
Zhenyi Qiao, Huanchang Zhang, Hong Zou, Yaqi Meng, Lan Duo, Xue Wang, Qinglian Xie, Xiaofei Fu, Weiwei Qi, Chunping You   +9 more
wiley   +1 more source

SARS-CoV-2 sublineages recovered from southern Brazilian cases during Omicron wave in 2023, early introduction of JN.1. [PDF]

Braz J Infect Dis
Fontes-Dutra M, Filippi M, Demoliner M, Sita A, Spilki FR.   +4 more
europepmc   +1 more source

Engineering Gossypol‐Free Cottonseeds for Future Global Food Security and Agricultural Sustainability

Food Frontiers, EarlyView.
This study depicting the role of transcriptomics, RNA interference (RNAi), and CRISPR/Cas9 technologies in the breeding of glandless cottonseed and glanded cotton tissues. This approach demonstrates the potential of cotton as a dual‐purpose crop, serving both the fiber industry and as a sustainable food and feed source.
Teame Gereziher Mehari, Muhammad Yousaf Shani, Junfeng Tang, Hui Fang, Muhammad Jawad Umer, Fang Liu, Kai Wang, Dengbing Yao, Muhammad K. R. Khan, Baohua Wang   +9 more
wiley   +1 more source

High-resolution <i>Staphylococcus</i> profiling reveals intra-species diversity in a single skin niche. [PDF]

Microb Genom
Herman R, West DT, Meaden S, Khan I, Cornmell R, Hunt J, Rudden M, Wilkinson HN, Hardman MJ, Wilkinson AJ, Murphy B, Thomas GH.   +11 more
europepmc   +1 more source

Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing

Advanced Genetics, EarlyView.
This review examines recent advances in Oxford Nanopore Technologies direct RNA sequencing, highlighting its expanding capacity to detect RNA modifications beyond m6A. It discusses computational frameworks and basecalling innovations that enable single‐nucleotide and single‐molecule resolution, explores co‐occurring modifications and their regulatory ...
Yaran Liu, Yang Li, Qiang Sun
wiley   +1 more source