Results 231 to 240 of about 373,405 (315)

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Comprehensive Genomic Profiling for Precision Oncology: Analytical Validation and Clinical Utility in Solid Tumors. [PDF]

Diagnostics (Basel)
Mondal AK, Vashisht A, Vashisht V, Sahajpal NS, Omar N, Ananth S, Ahluwalia PK, Farmaha J, Woodall J, Kolhe R.   +9 more
europepmc   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Virome Analysis of Lemon Plants with Vein Clearing Symptoms Reveals Mixed Infection of Citrus Vein Clearing Virus, Iris Domestica Betaflexivirus 1 and Hop Stunt Viroid. [PDF]

Viruses
Kwak M, Kil EJ, De Stradis A, Parrella G.   +3 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

An Improved Chromosome-Level Genome Assembly and Comprehensive Annotation of the Model Ascidian Ciona savignyi. [PDF]

Sci Data
Huang X, Zhan A.
europepmc   +1 more source

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Blood, 2016
Ilenia Simeoni, J. Stephens, Fengyuan Hu, Sri V. V. Deevi, K. Megy, T. Bariana, C. Lentaigne, Sol Schulman, S. Sivapalaratnam, Minka J. A. Vries, S. Westbury, D. Greene, S. Papadia, M. Alessi, A. Attwood, M. Ballmaier, Gareth Baynam, E. Bermejo, M. Bertoli, P. Bray, L. Bury, M. Cattaneo, P. Collins, L. Daugherty, R. Favier, D. French, B. Furie, M. Gattens, M. Germeshausen, C. Ghevaert, A. Goodeve, J. Guerrero, D. Hampshire, D. Hart, J. Heemskerk, Y. Henskens, M. Hill, N. Hogg, J. Jolley, W. Kahr, A. Kelly, R. Kerr, Myrto A. Kostadima, S. Kunishima, Michele P. Lambert, R. Liesner, José A López, R. Mapeta, M. Mathias, C. Millar, A. Nathwani, M. Neerman-Arbez, A. Nurden, P. Nurden, M. Othman, K. Peerlinck, D. Perry, Pawan Poudel, P. Reitsma, M. Rondina, P. Smethurst, W. Stevenson, Artur Szkotak, Salih Tuna, C. van Geet, Deborah Whitehorn, D. Wilcox, Bin Zhang, S. Revel-Vilk, P. Gresele, D. Bellissimo, C. Penkett, M. Laffan, A. Mumford, A. Rendon, K. Gomez, K. Freson, W. Ouwehand, E. Turro   +78 more
semanticscholar   +1 more source

Functionally complementary bacterial inoculant coordinates arbuscular mycorrhizal fungi to improve Angelica sinensis root yield and quality

iMetaOmics, EarlyView.
Comprehensive understanding of how diverse PGPR strains enhance the rhizosphere microenvironment remains a considerable challenge. Here, we provide experimental evidence that a functionally synergistic composite microbial formulation can markedly enhance growth performance and improve the quality attributes in Angelica sinensis.
Zongyu Zhang, Yun Wang, Jiecai Zhao, Gaofeng Chen, Andéole Niyongabo Turatsinze, Liang Yue, Yuan Tian, Xiaofan Xie, Ailing Ye, Meilan Zhang, Lingling Wu, Zengxiang Guo, Yubao Zhang, Ruoyu Wang   +13 more
wiley   +1 more source

Towards standardization in pig microbiome research based on a comprehensive twenty-year review. [PDF]

Anim Microbiome
Enokela SO, Yergaliyev T, Flisikowski K, Hornburg SC, Reyer H, Tetens J, Wimmers K, Zentek J, Camarinha-Silva A.   +8 more
europepmc   +1 more source

In Silico Identification of RNA Modifications from High-Throughput Sequencing Data Using HAMR.

Methods in molecular biology, 2017
Pavel P. Kuksa, Y. Leung, Lee E. Vandivier, Zachary D Anderson, B. Gregory, Li-San Wang   +5 more
semanticscholar   +1 more source