Results 261 to 270 of about 373,405 (315)

Development of a multiplex SNaPshot assay for simultaneous detection of multiple insecticide-resistance mutations in Anopheles sinensis. [PDF]

Parasit Vectors
Xin Y, Yue Z, Yan S, Yu C, Liu M, Yang S, Xie R, Zheng B, Yin J, Xu B.   +9 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

The development and validation of a genotyping-by-target sequencing chip for fungal population genetic analysis. [PDF]

Stress Biol
Yan H, Ma Z, Yao Q, Cao S, Jia Q, Li J, Zhao J, Yan W, Ma J, Chen W, Zhang B, Ma X, Wang X, Han D, Kang Z, Huang L, Zeng Q.   +16 more
europepmc   +1 more source

Nanopore Sequencing for HPV in Oropharyngeal Squamous Cell Carcinoma and Benign Tonsil Specimens

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objectives Human papillomavirus (HPV) accounts for the majority of oropharyngeal squamous cell carcinoma (OPSCC) cases in the United States but understanding the prevalence of high‐risk HPV in oropharyngeal tissue remains poor. We evaluated nanopore sequencing, a novel rapid, and long‐read sequencing platform, on OPSCC tissue and tested it in ...
Mikayla G. Hubbard, Guang‐Sheng Lei, Robert Emerson, Danielle Schreiber, Thomas E. Davis, Diane W. Chen   +5 more
wiley   +1 more source

Metagenomic screening of the virome of symptomatic tomato plants from La Réunion Island uncovers a complex of viruses including a newly identified whitefly-transmitted polerovirus. [PDF]

Arch Virol
Lett JM, Scussel S, Chéhida SB, Hoareau M, Filloux D, Fernandez E, Roumagnac P, Parvedy E, Quirin E, Clain C, Minatchy J, Roux E, Teycheney PY, Lefeuvre P.   +13 more
europepmc   +1 more source

Evaluating the Utility of RNAseq in Prenatal Diagnostics: Expression Profiles of Cultured Chorionic Villus and Amniotic Fluid Samples

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective While RNAseq has enhanced variant interpretation in postnatal cases, its potential in the prenatal setting remains underexplored. This study investigates the utility of RNAseq in prenatal diagnostics by analyzing the expression profiles of cultured chorionic villus samples (cCVS) and amniotic fluid (cAF) samples. Methods We performed
Maria C. Vladoiu, Sen Zhao, Roni Zemet, Christian M. Parobek, Jefferson Cruz Sinson, Stacy Tankersley, Ignatia B. Van den Veyver, Pengfei Liu   +7 more
wiley   +1 more source

Metagenomics Analysis of Viruses Associated with Cassava Brown Streak Disease in Kenya. [PDF]

Viruses
Munguti FM, LaTourrette K, Silva G, Maina S, Kilalo DC, Macharia I, Mwango'mbe AW, Nyaboga EN, Garcia-Ruiz H.   +8 more
europepmc   +1 more source

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, EarlyView.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source

High-Throughput DNA Sequencing Reveals Gastric Content Composition and Inter-Specific Variation in <i>Pampus</i> Fishes. [PDF]

Ecol Evol
Weiji W, Chengbin L, Ding L, Yulong H, Guanzheng L, Xiujuan S.   +5 more
europepmc   +1 more source

Life after herbarium digitisation: Physical and digital collections, curation and use

PLANTS, PEOPLE, PLANET, EarlyView.
Societal Impact Statement Collections of dried plant specimens (herbaria) provide an invaluable resource for the study of many areas of scientific interest and conservation globally. Digitisation increases access to specimens and metadata, enabling efficient use across a broad spectrum of research.
Alan James Paton, Gabriel K. Ameka, Alexandre Antonelli, Alex Asase, Russell L. Barrett, Ann Bogaerts, Domingos Cardoso, Mark Carine, Alastair Culham, Syadwina H. Dalimunthe, Nina Davies, Sofie De Smedt, Sebebe Demissew, Rafaela Campostrini Forzza, Quentin Groom, Elspeth M. Haston, Abdulrokhman Kartonegoro, Paul Kersey, Isabel Larridon, Jana Leong‐Škorničková, Lucia G. Lohmann, Jehova Lourenco Jr., Hannah McPherson, Muthama Muasya, Nicky Nicolson, Marcelo Pace, Jack F. Plummer, Hélène Ralimanana, Himmah Rustiami, Hervé Sauquet, Emily B. Sessa, Eric Smets, Alex Sumadijaya, Jordan Teisher, Daniel C. Thomas, Eka F. Tihurua, Janine E. Victor, Sarah T. Wagner, Quiang Wang, Andrew Young   +39 more
wiley   +1 more source