Results 171 to 180 of about 5,794,747 (285)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Teaching High-Value Care on Rounds [PDF]

JAMA Internal Medicine, 2016
Rachel J, Stern, Anna L, Parks
openaire   +2 more sources

Intensive Medical Care and Cardiovascular Disease Disability Reductions [PDF]

There is little empirical evidence to explain why disability declined among the elderly over the past 20 years. In this paper, we explore the role of improved medical care for cardiovascular disease on health status improvements over time.
David M. Cutler, Kate A. Stewart, Mary Beth Landrum   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

High-Value Care Inclusion in the Preclinical and Clinical Years of Medical School: A Narrative Review and Descriptive Experience at a Single Institution. [PDF]

Cureus
Storm LK, Salvemini JD, Shields ML, Harris SK, Roux JA, Couey CC, Yang J, Doherty CG, Overton JS, Jeter JB.   +9 more
europepmc   +1 more source

High-value care through better care coordination? [PDF]

International Journal of Care Coordination, 2017
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lifestyle Medicine as a Framework for High-Value Care: A Position Statement From the American College of Lifestyle Medicine. [PDF]

Am J Lifestyle Med
Marshall S, Patel P, Anand R, Artz K, Collins A, Grega M, Gulati M, Hemmingson TA, Mansfield S, Nathan A, Pauly K, Sugden SG, Tivnan V, Wilson A, Staffier KL.   +14 more
europepmc   +1 more source

Demonstration of high value care to improve oral health of a remote Indigenous community in Australia. [PDF]

Health Qual Life Outcomes, 2020
Kularatna S, Lalloo R, Kroon J, Tadakamadla SKK, Scuffham PA, Johnson NW.   +5 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source