Results 111 to 120 of about 3,603,990 (303)

ERAPSO: Revealing the High Burden of Obesity in German Psoriasis Patients

Dermatology and Therapy, 2019
Introduction Plaque psoriasis is a chronic, systemic-inflammatory disease characterized by skin erythema, plaques and scaling, and is associated with different comorbidities like psoriatic arthritis, obesity, and cardiometabolic diseases.
Peter E. H. Schwarz, Andreas Pinter, Nima Melzer, Philipp Barteczek, Maximilian Reinhardt   +4 more
doaj   +1 more source

The WorkPlace distributed processing environment [PDF]

Real time control problems require robust, high performance solutions. Distributed computing can offer high performance through parallelism and robustness through redundancy.
Ames, Troy, Henderson, Scott
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

High-functioning depression: a hidden burden demanding clinical recognition

BJPsych Bulletin
High-functioning depression (HFD) describes individuals experiencing persistent depressive symptoms, such as low mood and emotional exhaustion, while maintaining outward success.
Promise U. Okereke, Chukwuemeka V. Umeh, Wisdom O. Okereke, Egide Ndayambaje, Christian C. Obetta, Onyedikachi F. Uzor, Olanrewaju J. Oduola   +6 more
doaj   +1 more source

Radiation Burden in High-Resolution CT of the Lungs

Acta Radiologica, 1995
Acta ...
Kalef-Ezra, J. A., Karantanas, A. H.
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Global burden of high sugar-sweetened beverage consumption among young adults

Diabetology & Metabolic Syndrome
Background and aims High sugar-sweetened beverage (SSB) consumption is a growing public health concern linked to obesity and chronic diseases. This study analyzed global trends and disparities in high SSB consumption among young adults aged 15–39 years ...
Chenliang Ge, Jingwei Xiong, Rui Zhu, Zhenchen Hong, Yan He   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source