Results 121 to 130 of about 17,674,253 (266)

Hearing-Functioning Problems Across High-Burden Adult Health Conditions in Africa. [PDF]

Int J Environ Res Public Health
Dawood G, Maart R, Louw QA.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Frontline healthcare worker barriers impacting tuberculosis service demand and access in high burden settings: a scoping review. [PDF]

J Glob Health
Cox SR, Hanrahan CF, Moe AH, Shearer K, Christian C, Sethi S, Hudson M, Ueshima M, Singh K, Dawson J, Angami K, Kubai N, Namasivayam M, Shete P, Golub JE, Kerkhoff AD.   +15 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spontaneous Metabolic Regression in High-Burden Follicular Lymphoma: A Case Report. [PDF]

Case Rep Hematol
Bronstein Y, Vitkon R, Hayman L, Perry C.   +3 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Non-tuberculous mycobacterial disease in a high TB/HIV burden setting

IJTLD Open
S. Janssen, Z. Ismail, T. Lovelock, S. Hugo, M. van Schalkwyk, A. Parker, B.W. Allwood, C.F.N. Koegelenberg, J. van Ingen, A. van Laarhoven, T. Mabuka, H. Prozesky, J. Taljaard   +12 more
doaj   +1 more source

Barriers to accessing newer antibiotics in countries with high burden of bacterial antimicrobial resistant infections-a qualitative study. [PDF]

Lancet Reg Health West Pac
Singh SR, Blanco-Arévalo A, Gupta A, Chee JY, Aligui AAAF, Hor SW, Shou Y, Saravanan R, Leong J, Charani E, Mo Y.   +10 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Identifying and quantifying ESKAPEE pathogens in and around sinks in high burden hospitals. [PDF]

J Hosp Infect
Saber LB, Rojas M, Blakley IC, Sun S, Lott MEJ, Fodor AA, Toledo CC, Brown J.   +7 more
europepmc   +1 more source