Results 111 to 120 of about 17,674,253 (266)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

High Burden of Goat Gastrointestinal Nematodes in South Ethiopia: Prevalence, Species Composition and Determinants of Infection. [PDF]

Vet Med Sci
Dulo F, Alaro T.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Asian consensus on diagnostic algorithm for invasive pulmonary fungal diseases in high-burden settings. [PDF]

J Transl Int Med
Fang W, Liu X, Bilal H, Habib MD, Hanifi AN, Momin NWS, Lass-Flörl C, Samnang C, An L, Cao C, Chen M, Chen Z, Deng S, Fan L, Gong J, Gu B, Guo J, Huang X, Kang Y, Liang G, Lin L, Liu J, Liu W, Liu S, Liu W, Li Z, Li Z, Lu B, Lu Z, Ni Y, Qin X, Qiu H, Qu Y, Shi D, Shi Y, Su X, Tang H, Wang M, Wang Y, Wang J, Wu W, Xu B, Xu J, Xu Y, Ye F, Yu Y, Zhu L, Zhou L, Zong Z, Gemechu A, De Mandal S, Gaur P, Barchiesi F, Caggiano G, Abbasi B, Jamaati HR, Ganji SM, Ahmed SA, Alobaid K, Than LTL, Al-Hatmi AMS, Amir A, Mehmood I, Rahman M, Sudhadham M, İlkit M, Hoa PQ, Wang H, Nhung PH, Thi TD, Liao W, Huang X, Pan W.   +72 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Rapid diagnosis of pulmonary tuberculosis on induced sputum in children in a high burden setting for HIV and malnutrition. [PDF]

PLOS Glob Public Health
Luiz J, Workman LJ, Baard CB, Hlombe Y, Prins M, Makubalo N, Jaganath D, Cattamanchi A, Nicol MP, Zar HJ.   +9 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Cured but not healed: high burden of pulmonary disability and multimorbidity among TB survivors in India. [PDF]

Public Health Action
Subramanian S, Thekkur P, Chinnakali P, Tripathy JP, Ramaswamy G, Venugopal V, Sehgal IS, Soundappan K, Naik P, Nair D, Malegaonkar S, Babu VM, Jothula KY, Malik A, Devaraj L, Rajaram M, Sarkar S, Harries AD, Zachariah R.   +18 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source