Results 171 to 180 of about 3,603,990 (303)

Global status of policies and practices for systematic TB screening in high-burden countries. [PDF]

IJTLD Open
Innes AL, Matji R, Menzies D, Rade K, Alacapa J, Sanni B, Qadeer E, Kak N, Paydar A, Kumar N, Pakasi TT, Chijoke-Akaniro O, Ismail M, Fabella RA, Ndjeka N, Burua A, Dinh VL, Falzon D, Miller CR.   +18 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Non-tuberculous mycobacterial disease in a high TB/HIV burden setting

IJTLD Open
S. Janssen, Z. Ismail, T. Lovelock, S. Hugo, M. van Schalkwyk, A. Parker, B.W. Allwood, C.F.N. Koegelenberg, J. van Ingen, A. van Laarhoven, T. Mabuka, H. Prozesky, J. Taljaard   +12 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

High burden of geriatric assessment impairments across the adult age spectrum in patients with cancer. [PDF]

Oncologist
Nien CT, Chang CY, Lu CH, Yeh KY, Hung YS, Chou WC.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Delays in tuberculosis care among the top-ten-tuberculosis-high burden countries in the world: a scoping review. [PDF]

J Egypt Public Health Assoc
Samal J, Preetha GS, Singh H.
europepmc   +1 more source

Travel To High Burden Tuberculosis Country [PDF]

, 2020
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

High Burden of Febrile Sub-microscopic Plasmodium Mixed Infections in Central India: A Cross-Sectional Study. [PDF]

Infect Dis Ther
Deora N, Pande V, Pal DK, Sharma H, Dube S, Sinha A.   +5 more
europepmc   +1 more source