FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Potential of Silver Nanoparticles in Imaging Diagnostics and Image-Guided Applications: A Narrative Review. [PDF]
Pharmaceuticals (Basel)Gledacheva V, Nikolova S.
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
CT Radiation Dose Reduction With Preserved Diagnostic Performance: How Far Have We Come Over 25 Years? [PDF]
AJR Am J RoentgenolMcCollough CH, Yu L.
europepmc +1 more source
Applications of High-Contrast Imaging Techniques and Polarimetry to (Exo-)Planetary Science [PDF]
The goal of this thesis is to characterize circumstellar disks and substellar objects, from moons to brown dwarfs, by improving and applying techniques from high-contrast imaging.
Lewis, Briley Lynn
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Comparing Laboratory and Synchrotron X-Ray CT for Structural Analysis of PEEK Orthopedic Implants. [PDF]
Biomimetics (Basel)Qi M +5 more
europepmc +1 more source
Low-rank techniques for exoplanet detection in high contrast images
“Is there life beyond Earth?“ This question has captivated humanity for centuries, driving efforts to discover planets beyond our solar system. Among the various techniques developed for exoplanet detection, direct imaging stands out as one of the most promising, as it allows for the direct capture of signals from planets themselves.
openaire +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Advances in the application of different imaging techniques in percutaneous lung biopsy. [PDF]
Front Med (Lausanne)Zhao Z +6 more
europepmc +1 more source