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High-density lipoproteins and atherosclerosis
The American Journal of Cardiology, 2002High-density lipoproteins (HDLs) are strongly related to risk of atherosclerotic cardiovascular disease. Low levels of HDL cholesterol are a major cardiovascular risk factor, and overexpression of the major HDL protein, apolipoprotein (apo) A-I, markedly inhibits progression and even induces regression of atherosclerosis in animal models. Clinical data
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High Density Lipoproteins in Diabetes
Diabetes, 1981The concentration of high density lipoproteins (HDL) in patients with diabetes mellitus is highly variable. Subnormal HDL cholesterol levels are present in untreated patients with insulin-deficient juvenile diabetes, but the values return to the normal range after beginning insulin therapy.
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Antidiabetic role of high density lipoproteins
Biomeditsinskaya Khimiya, 2018Disturbance in lipid metabolism can be both a cause and a consequence of the development of diabetes mellitus (DM). One of the most informative indicator of lipid metabolism is the ratio of atherogenic and antiatherogenic fractions of lipoproteins and their protein components.
O N, Poteryaeva, I F, Usynin
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Proteomic analysis of high‐density lipoprotein
PROTEOMICS, 2006AbstractPlasma lipoproteins, such as high‐density lipoprotein (HDL), can serve as carriers for a wide range of proteins that are involved in processes such as lipid metabolism, thrombosis, inflammation and atherosclerosis. The identification of HDL‐associated proteins is essential with regards to understanding these processes at the molecular level. In
Rezaee, Farhad +4 more
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High-density lipoprotein turnover
American Heart Journal, 1987High-density lipoprotein (HDL) metabolism has been reviewed from information derived from turnover studies in humans. The two major HDL apoproteins AI and AII have different removal rates, reflecting the faster catabolism of HDL2 than of HDL3. This is caused by the continual cycle of formation of HDL2 from HDL3 and its reversion to HDL3, in response to
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High-Density Lipoprotein Metabolism
1980Publisher Summary Cholesterol is an essential structural component of all cell membranes. The cholesterol of extrahepatic tissues appears to be derived from receptor-mediated uptake of plasma low-density lipoprotein, to a lesser extent from endogenous synthesis, and also from direct transfer from cholesterol-rich lipoproteins. Most tissues are unable
A, Nicoll, N E, Miller, B, Lewis
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Modified Low-Density Lipoproteins and High-Density Lipoproteins
Pathophysiology of Haemostasis and Thrombosis, 2006It has long been known that the oxidative state of the various plasma lipoproteins modulates platelet aggregability, thereby contributing to atherogenesis. Low-density lipoprotein (LDL), occurring in vivo both in the native and oxidised forms, interacts directly with platelets, by binding to specific receptors.
Elisabeth Koller +3 more
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High-density lipoprotein subclasses
Current Opinion in Lipidology, 1994This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP), lecithin:cholesterol ...
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Interrelationship of triglycerides with lipoproteins and high-density lipoproteins
The American Journal of Cardiology, 1990Triglycerides are transported by the largest and most lipid-rich of the lipoprotein particles, namely, chylomicrons and very low density lipoproteins (VLDL). These particles are buoyant because of the high triglyceride content, which makes up approximately 90% by weight of the chylomicron and 70% by weight of the VLDL.
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