Results 111 to 120 of about 16,622,247 (250)
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Advanced Science, EarlyView.Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park +13 more
wiley +1 more source
, 2008 Navin K Kapur, Dominique Ashen, Roger S BlumenthalDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Since the pioneering work of John Gofman in the 1950s, our understanding of high density lipoprotein ...
Roger S Blumenthal +2 more
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High-density lipoprotein cholesterol and multiple sclerosis: a systematic review and meta-analysis
Introduction Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. Evidence has shown that lipid metabolism is associated with MS clinical outcomes.
Dimitrios Papadopoulos +6 more
core +1 more source
Advanced Science, EarlyView.Cygnus (Cyclic‐imaging gateway to nanovesicles underlying signature) integrates multiplexed single‐EV protein imaging with a practical analysis workflow to examine EV phenotypes at vesicle, subpopulation, and sample scales. ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally ...
Mi Hyeon Cho +13 more
wiley +1 more source
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
High-density lipoprotein functionality in systemic lupus erythematosus
, 2020 High-density lipoprotein functionality in systemic lupus ...
Shiva Ganjali (14682088) +3 more
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High-density lipoprotein and the risk of recurrent venous Thromboembolism
, 2007 Background: high-density lipoprotein (HDL) protects against arterial atherothrombosis, but it is unknown whether it protects against recurrent venous thromboembolism.
Griffin, John H. +13 more
core +1 more source
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Association of the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Neutrophil to High-Density Lipoprotein Cholesterol Ratio With the Severity of New-Onset Coronary Artery Disease [PDF]
Hongyun Shu,1,* Sisi Han,1,* Weiping Qiu,1 Jianhong Li,1 Xiaoyong Zhang,1 Haicui Su,1 Hongjie Wu,2 Guojun Zhao,1 Qiaowen Li3 1Department of Cardiovascular Medicine, The Affiliated Qingyuan Hospital (Qingyuan People’s Hospital) of Guangzhou ...
Qiu W +8 more
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