Results 91 to 100 of about 2,028,498 (355)

High density lipoprotein cholesterol: an evolving target of therapy in the management of cardiovascular disease [PDF]

, 2008
Navin K Kapur, Dominique Ashen, Roger S BlumenthalDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USAAbstract: Since the pioneering work of John Gofman in the 1950s, our understanding of high density lipoprotein ...
Roger S Blumenthal, Navin K Kapur, Dominique Ashen   +2 more
core  

High-density lipoprotein cholesterol and multiple sclerosis: a systematic review and meta-analysis [PDF]

Introduction Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. Evidence has shown that lipid metabolism is associated with MS clinical outcomes.
Dimitrios Papadopoulos, Aris P. Agouridis, Evangelos C. Rizos, Anastasios Makris, Nikoletta Palli, Angelos Liontos, Constantinos Tsioutis   +6 more
core   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

High-density lipoprotein and the risk of recurrent venous Thromboembolism [PDF]

, 2007
Background: high-density lipoprotein (HDL) protects against arterial atherothrombosis, but it is unknown whether it protects against recurrent venous thromboembolism.
Griffin, John H., Pecheniuk, N. M., Hron, G., Deguchi, H., Kyrle, Paul A., Eichinger, S., Griffin, J. H., Kyrle, P. A., Hron, Gregor, Deguchi, Hiroshi, Eichinger, Sabine, Pecheniuk, Natalie M., Schemper, Michael, Schemper, M.   +13 more
core   +1 more source

HDL-apolipoprotein A-I exchange is independently associated with cholesterol efflux capacity

Journal of Lipid Research, 2015
HDL is the primary mediator of cholesterol mobilization from the periphery to the liver via reverse cholesterol transport (RCT). A critical first step in this process is the uptake of cholesterol from lipid-loaded macrophages by HDL, a function of HDL ...
Mark S. Borja, Kit F. Ng, Angela Irwin, Jaekyoung Hong, Xing Wu, Daniel Isquith, Xue-Qiao Zhao, Bryan Prazen, Virginia Gildengorin, Michael N. Oda, Tomáš Vaisar   +10 more
doaj   +1 more source

Protein Corona Formation on Soft Nanocarriers Under Biomimetic Circulatory Flow

Advanced Materials Interfaces, EarlyView.
A biomimetic venous circulation system is developed to study protein corona formation on soft nanocarriers under physiological shear. Liposomes, PLGA nanoparticles, and lipid‐polymer hybrid nanoparticles acquire largely shared but material‐dependent protein coronas that alter surface properties and suppress cellular uptake, highlighting the importance ...
Anamarija Nikoletić, Dominik Simon Müller, Timon Flathmann, Jakob Steuer, Evangelos Natsaridis, Chiara Candino, Abdullah Kahraman, Oya Tagit   +7 more
wiley   +1 more source

High-density lipoprotein functionality in systemic lupus erythematosus [PDF]

, 2020
High-density lipoprotein functionality in systemic lupus ...
Shiva Ganjali (14682088), L Shirmohammadi (18978296), A Sahebkar (7797281), MI Read (18978299)   +3 more
core  

A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans

Journal of Lipid Research, 2017
Reverse cholesterol transport (RCT) is thought to be an atheroprotective function of HDL, and macrophage-specific RCT in mice is inversely associated with atherosclerosis.
Marina Cuchel, Anna C. Raper, Donna M. Conlon, Daniel A. Pryma, Richard H. Freifelder, Rahul Poria, Debra Cromley, Xiaoyu Li, Richard L. Dunbar, Benjamin French, Liming Qu, William Farver, Ching-Chiang Su, Sissel Lund-Katz, Amanda Baer, Giacomo Ruotolo, Peter Akerblad, Carol S. Ryan, Lan Xiao, Todd G. Kirchgessner, John S. Millar, Jeffrey T. Billheimer, Daniel J. Rader   +22 more
doaj   +1 more source

High-density lipoprotein impedes glycation of low-density lipoprotein

Diabetes and Vascular Disease Research, 2012
Glycation of low-density lipoprotein (LDL) increases its atherogenicity, but whether high-density lipoprotein (HDL) can protect LDL against glycation is not known. LDL and HDL were isolated from 32 volunteers with serum HDL cholesterol concentrations ranging from 0.76 to 2.01 (mean = 1.36) mmol/L.
Nahla N, Younis, Handrean, Soran, Valentine, Charlton-Menys, Reena, Sharma, Salam, Hama, Philip, Pemberton, Mohamed M, Elseweidy, Paul N, Durrington   +7 more
openaire   +2 more sources

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source