Results 71 to 80 of about 16,622,247 (250)

Hepatic lipase activity is lower in African American men than in white American men: effects of 5′ flanking polymorphism in the hepatic lipase gene (LIPC)

Journal of Lipid Research, 1998
Plasma high density lipoprotein cholesterol (HDL-C) concentrations are higher in African American men than in white men, but the mechanism(s) responsible for this ethnic difference has not been elucidated.
Gloria Lena Vega, Luther T. Clark, Aylmer Tang, Santica Marcovina, Scott M. Grundy, Jonathan C. Cohen   +5 more
doaj   +1 more source

Arginine-directed glycation and decreased HDL plasma concentration and functionality [PDF]

, 2014
Background/Objectives: Decreased plasma concentration of high-density lipoprotein cholesterol (HDL-C) is a risk factor linked to increased risk of cardiovascular disease (CVD). Decreased anti-atherogenic properties of HDL are also implicated in increased
Rabbani, Naila, Smith, L., Godfrey, L. (Lisa), Thornalley, Paul J., Yamada-Fowler, N. (Naomi)   +4 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Lipoprotein separation in a novel iodixanol density gradient, for composition, density, and phenotype analysis

Journal of Lipid Research, 2008
Separation of lipoproteins by traditional sequential salt density floatation is a prolonged process (∼72 h) with variable recovery, whereas iodixanol-based, self-generating density gradients provide a rapid (∼4 h) alternative.
Michael S. Yee, Darrell V. Pavitt, Tira Tan, Soundararajan Venkatesan, Ian F. Godsland, William Richmond, Desmond G. Johnston   +6 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Low-Density Lipoprotein and High-Density Lipoprotein as Biomarkers for Inflammatory Bowel Disease Activity Assessment

International Journal of General Medicine
Xi Zhao,1,* Wei Yan,2,* Li Wang,3,* Qinyu Feng,1 Yingzhi Pang,2 Yanping Wang,1 Meihui Tao,1 Jingyue Zhang,1 Yu Fu1 1Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and ...
Zhao X, Yan W, Wang L, Feng Q, Pang Y, Wang Y, Tao M, Zhang J, Fu Y   +8 more
doaj  

Effect of Poloxamer 407 on serum VLDL, LDL and HDL levels of rabbits

National Journal of Physiology, Pharmacy and Pharmacology, 2014
Background: Poloxamer 407 is used in parenteral formulations as solubilizing and wetting agent for traditional, low-molecular-weight organic drug molecules and as stabilizing agent for proteins and polypeptide drugs.
Harish Govind Naik, Ashwini Kolur, Dundesh Maled, Chitra C Khanwelkar, Rohit Desai, Sunil Gidamudi   +5 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Plasma levels of lipoprotein-associated phospholipase A2 are increased in patients with β-thalassemia

Journal of Lipid Research, 2010
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent cardiovascular risk factor. We investigated the plasma levels of Lp-PLA2 activity and mass as a function of plasma lipid levels, LDL subclass profile, and oxidative stress in patients ...
Alexandros D. Tselepis, George Hahalis, Constantinos C. Tellis, Eleni C. Papavasiliou, Panagiota T. Mylona, Alexandra Kourakli, Dimitrios C. Alexopoulos   +6 more
doaj   +1 more source