Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes
ChemElectroChem, EarlyView.This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský +5 more
wiley +1 more source
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and telomere length: the NHANES 1999-2002. [PDF]
Front Cardiovasc MedLiu M, Wang C, Wei B.
europepmc +1 more source
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
Clinical Pharmacology &Therapeutics, EarlyView.The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou +6 more
wiley +1 more source
Systemic inflammation partially mediates the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and chronic cough. [PDF]
Lipids Health DisWang C, Liao X, Chen J, Lan Y, Wen J.
europepmc +1 more source
Photochemistry of Resveratrol: Beyond the Reactivity of Metal‐Free Porphyrins Immobilized on Lignin
ChemPhotoChem, EarlyView.Resveratrol photochemistry with singlet oxygen is examined at 450 nm using blue‐LED irradiation and various homogeneous and heterogeneous photosensitizers. Products of CC bond cleavage, electrocyclic ring closure, and [4 + 2] cycloaddition are identified.
Elisa De Marchi +8 more
wiley +1 more source
The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and its combination with obesity indicators as a predictor of all cause and cardiovascular mortality in non-diabetic individuals. [PDF]
BMC Public HealthLiang J +10 more
europepmc +1 more source
Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with coronary heart disease: Establishment and validation of a clinical nomogram model. [PDF]
Medicine (Baltimore)Ding W, Li T, Fang C, Zhang XX, Wang E.
europepmc +1 more source
Developmental Dynamics, EarlyView.Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters +5 more
wiley +1 more source