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High-Density Lipoprotein and High-Density Lipoprotein Cholesterol
Biomarkers in Cardiovascular Disease, 2019Kayla A. Riggs, Anand Rohatgi
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High-Density Lipoprotein Infusions
Cardiology Clinics, 2018High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL.
Kohei Takata+2 more
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Quantitation of high density lipoproteins
Lipids, 1978AbstractThe demand for high density lipoprotein (HDL) quantitation has dramatically increased with the renewed awareness of the importance of HDL as a negative risk factor for coronary heart disease. HDL is usually estimated by specific precipitation of the non‐HDL apoB‐containing lipoproteins by polyanions and divalent cations followed by measurement ...
John J. Albers+2 more
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High-density lipoprotein subfractions
The American Journal of Medicine, 1993High-density lipoprotein (HDL) consists of a heterogeneous group of particles defined either by size or by apolipoprotein content. Subfractions of HDL appear to have distinct but interrelated metabolic functions, including facilitation of cholesteryl ester transfer to low- and very-low-density lipoproteins, modulation of triglyceride-rich particle ...
Geoffrey S. Ginsburg+2 more
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Plasma High-Density Lipoproteins
New England Journal of Medicine, 1978WHY all the recent excitement about highdensity lipoproteins (HDL)? Because of the strong inverse relation between plasma levels of HDL and mortality from cardiovascular disease.1,2 Increased serum...
Donald Small, Alan R. Tall
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High density lipoprotein and lipoprotein oxidation
Current Opinion in Lipidology, 1996HDL protects LDL from oxidative damage known to contribute to the onset and progression of atherosclerosis. This antioxidant protection by HDL is mediated by intrinsic hydrolytic enzyme systems, by accelerated selective uptake of lipid peroxides from HDL and by antioxidant molecules.
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Genetics of high-density lipoproteins [PDF]
High-density lipoproteins have multi-factorial anti-atherosclerosis properties: they have potent anti-oxidant effects and prevent the oxidation of low-density lipoproteins; they have anti-inflammatory effects; they modulate vascular endothelial cell function and transport cholesterol back to the liver for excretion into the bile - a process called ...
Zari Dastani+3 more
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High-Density Lipoprotein Mimetics: Focus on Synthetic High-Density Lipoprotein
The American Journal of Cardiology, 2007Epidemiologic studies show an inverse relation between high-density lipoprotein (HDL) cholesterol levels and coronary artery disease, and proof-of-concept experimental studies suggest that HDL and its apolipoproteins, specifically apolipoprotein (apo) A-I , have atheroprotective effects.
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High density lipoprotein structure
Frontiers in Bioscience, 2003HDL particles possess important antiatherogenic functionalities and understanding of the molecular mechanisms underlying these effects requires detailed knowledge of HDL structure. This review summarizes current understanding of HDL structure. The various HDL subclasses are compared in terms of their lipid and protein compositions.
Stephen T. Thuahnai+3 more
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High-density lipoprotein--the clinical implications of recent studies.
New England Journal of Medicine, 1989DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in athero...
D. Gordon, B. Rifkind
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