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High-Density Lipoprotein Metabolism
2000High-density lipoprotein (HDL) cholesterol concentrations are inversely associated with coronary heart disease (CHD) in humans [1,2]. The initial descriptions of this inverse relationship in the early 1950s [3–5] were “rediscovered” in the 1970s [6–9].
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2007
Low plasma levels of cholesterol carried by high-density lipoprotein (HDL) particles are firmly established as a major cardiovascular risk factor. Paradoxically, cardiovascular mortality is also elevated at extremely high levels of HDL cholesterol. Furthermore, genetic epidemiology often does not support a causal relationship between HDL cholesterol ...
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Low plasma levels of cholesterol carried by high-density lipoprotein (HDL) particles are firmly established as a major cardiovascular risk factor. Paradoxically, cardiovascular mortality is also elevated at extremely high levels of HDL cholesterol. Furthermore, genetic epidemiology often does not support a causal relationship between HDL cholesterol ...
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Exercise and High-Density Lipoproteins
JAMA: The Journal of the American Medical Association, 1979Ever since high-density lipoprotein (HDL)-cholesterol, as a measure of the HDLs, was found to be elevated in crosscountry skiers 1 and marathon runners, 2 investigators have debated whether this is a self-selection phenomenon, ie, skinny athletic persons naturally have higher HDL levels and are attracted to long-distance competitive sports because they
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High Density Lipoproteins in Diabetes
Diabetes, 1981The concentration of high density lipoproteins (HDL) in patients with diabetes mellitus is highly variable. Subnormal HDL cholesterol levels are present in untreated patients with insulin-deficient juvenile diabetes, but the values return to the normal range after beginning insulin therapy.
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High Density Lipoproteins in Cholestasis
Scandinavian Journal of Gastroenterology, 1974Blomhoff, J. P. High density lipoproteins in cholestasis. Scand. J. Gastroent. 1974, 9, 591–596.Two patients with cholestasis with increased concentration of plasma free cholesterol and phospholipi...
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High-density lipoprotein subclasses
Current Opinion in Lipidology, 1994This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP), lecithin:cholesterol ...
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Modified Low-Density Lipoproteins and High-Density Lipoproteins
Pathophysiology of Haemostasis and Thrombosis, 2006It has long been known that the oxidative state of the various plasma lipoproteins modulates platelet aggregability, thereby contributing to atherogenesis. Low-density lipoprotein (LDL), occurring in vivo both in the native and oxidised forms, interacts directly with platelets, by binding to specific receptors.
Franz Koller +3 more
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Platelet Activation by Low Density Lipoprotein and High Density Lipoprotein
Pathophysiology of Haemostasis and Thrombosis, 2006Cardiovascular disease is the main cause of death and disability in the Western society. Lipoproteins are important in the development of cardiovascular disease since they change the properties of different cells involved in atherosclerosis and thrombosis. The interaction of platelets with lipoproteins has been under intense investigation. Particularly
Jan-Willem N. Akkerman +1 more
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High-Density Lipoprotein Metabolism
1980Publisher Summary Cholesterol is an essential structural component of all cell membranes. The cholesterol of extrahepatic tissues appears to be derived from receptor-mediated uptake of plasma low-density lipoprotein, to a lesser extent from endogenous synthesis, and also from direct transfer from cholesterol-rich lipoproteins. Most tissues are unable
N. E. Miller, Barry Lewis, A. Nicoll
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The metabolism of high-density lipoproteins
Trends in Cardiovascular Medicine, 1994Although high-density lipoproteins (HDLs) have been shown to be the best single indicator of the risk of coronary heart disease (CHD), relatively little is known about their metabolism. Accordingly, only limited strategies are available for therapeutically raising plasma HDL levels.
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