Results 31 to 40 of about 1,232,763 (338)

A new lipid-structured model to investigate the opposing effects of LDL and HDL on atherosclerotic plaque macrophages [PDF]

arXiv, 2022
Atherosclerotic plaques form in artery walls due to a chronic inflammatory response driven by lipid accumulation. A key component of the inflammatory response is the interaction between monocyte-derived macrophages and extracellular lipid. Although concentrations of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles in the blood
arxiv  

Water insecurity, self‐reported physical health, and objective measures of biological health in the Peruvian Amazon

American Journal of Human Biology, Volume 34, Issue 12, December 2022., 2022
Abstract Objectives This study examines the associations between water insecurity, self‐reported physical health, and objective measures of biological health among 225 Awajún adults (107 women; 118 men) living in the Peruvian Amazon, a “water‐abundant” region.
Paula Skye Tallman, Shalean M. Collins, M. Pia Chaparro, Gabriela Salmon‐Mulanovich   +3 more
wiley   +1 more source

High density lipoprotein mimicking nanoparticles for atherosclerosis

Nano Convergence, 2020
Atherosclerosis is a major contributor to many cardiovascular events, including myocardial infarction, ischemic stroke, and peripheral arterial disease, making it the leading cause of death worldwide.
Jun Chen, Xixi Zhang, Reid Millican, Jacob Emil Creutzmann, Sean Martin, Ho-Wook Jun   +5 more
doaj   +1 more source

Maturation of high-density lipoproteins

Journal of The Royal Society Interface, 2009
Human high-density lipoproteins (HDLs) are involved in the transport of cholesterol. The mechanism by which HDL assembles and functions is not well understood owing to a lack of structural information on circulating spherical HDL. Here, we report a series of molecular dynamics simulations that describe the maturation of discoidal HDL into spherical HDL
Stephen G. Sligar, Amy Y. Shih, Klaus Schulten   +2 more
openaire   +4 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Nanobiotechnology applications of reconstituted high density lipoprotein

Journal of Nanobiotechnology, 2010
High-density lipoprotein (HDL) plays a fundamental role in the Reverse Cholesterol Transport pathway. Prior to maturation, nascent HDL exist as disk-shaped phospholipid bilayers whose perimeter is stabilized by amphipathic apolipoproteins.
Ryan Robert O
doaj   +1 more source

Role of Gamma Glutamyl Transferase in the Diagnosis of Metabolic Syndrome in Patients with Hypothyroidism [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Hypothyroidism is the most prevalent thyroid disorder in India that affects one in ten adults. Gamma Glutamyl Transferase (GGT) is an ectopic enzyme associated with oxidative stress in various diseased conditions.
ME Sumathi, K Prabhavathi, S Harish Kumar, KN Shashidhar, V Mahesh   +4 more
doaj   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

The High Density Lipoprotein Cholesterol Hypothesis Revisited

Indonesian Biomedical Journal, 2018
BACKGROUND: The strong inverse association of plasma levels of high-density lipoprotein cholesterol (HDL-C) with coronary heart disease (CHD) found in human epidemiological studies led to the development of the ‘HDL-C hypothesis’, which posits that ...
Anna Meiliana, Nurrani Mustika Dewi, Andi Wijaya   +2 more
doaj   +1 more source

Atherogenic Index of Plasma an Indicator for Predicting Cardiovascular Risk in Addition to Endothelial Dysfunction in Type 2 Diabetic Subjects [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Prevalence of Cardiovascular Disease (CVD) in diabetic subjects is higher than that in the general population. Dyslipidaemia is a known atherogenic factor which causes vascular complications in both general and diabetic population ...
Siva Prasad Palem, Philips Abraham
doaj   +1 more source