Results 31 to 40 of about 16,680,783 (298)

MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background MEDI6012 is recombinant human lecithin cholesterol acyltransferase, the rate‐limiting enzyme in reverse cholesterol transport. Infusions of lecithin cholesterol acyltransferase have the potential to enhance reverse cholesterol transport and ...
Richard T. George, Liron Abuhatzira, Susan M. Stoughton, Sotirios K. Karathanasis, Dewei She, ChaoYu Jin, Nicholas A. P. S. Buss, Rebecca Bakker‐Arkema, Emily L. Ongstad, Michael Koren, Boaz Hirshberg   +10 more
doaj   +1 more source

Mathematical model for low density lipoprotein (LDL) endocytosis by hepatocytes [PDF]

, 2008
Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk of developing coronary heart disease.
B. O’Malley, J. A. D. Wattis, H. Blackburn, Wattis, JA, H. M. Byrne, L. Pickersgill, O'Malley, B, Panovska, J, Pickersgill, L, Blackburn, H, Byrne, HM, Byrne, Helen, K. G. Jackson, Wattis, JAD, Jackson, KG, J. Panovska, Panovska, J., O'Malley, B., Pickersgill, L., Wattis, J.A.D., Jackson, K.G., Blackburn, H., Byrne, H.M.   +22 more
core   +1 more source

Hepatic lipase activity is lower in African American men than in white American men: effects of 5′ flanking polymorphism in the hepatic lipase gene (LIPC)

Journal of Lipid Research, 1998
Plasma high density lipoprotein cholesterol (HDL-C) concentrations are higher in African American men than in white men, but the mechanism(s) responsible for this ethnic difference has not been elucidated.
Gloria Lena Vega, Luther T. Clark, Aylmer Tang, Santica Marcovina, Scott M. Grundy, Jonathan C. Cohen   +5 more
doaj   +1 more source

Associations between remnant lipoprotein cholesterol and central systolic blood pressure in a Chinese community-based population: a cross-sectional study

Lipids in Health and Disease, 2021
Background The lipid profile is reportedly related to peripheral blood pressure or pulse wave velocity. However, no studies have investigated the associations between lipid parameters, especially remnant lipoprotein cholesterol (RLP-C), and central ...
Kaiyin Li, Fangfang Fan, Bo Zheng, Jia Jia, Bo Liu, Jiahui Liu, Chuyun Chen, Jing Zhou, Yan Zhang, Yong Huo   +9 more
doaj   +1 more source

The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans [PDF]

, 1997
Cafestol and kahweol–diterpenes present in unfiltered coffee— strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown.
de Roos, B, Tol, Aad, de Roos, B., de Jong-Caesar, R., Scheek, L.M., Urgert, R., Scheek, L. M., Gent, T, Caesar, R (Ruth), Gent, T. van, Katan, MB, Roos, B. de, van Tol, A., Jong-Caesar, R. de, van Gent, T., Tol, A. van, Scheek, LM (Leo), Urgert, R, Katan, M.B.; id_orcid, Katan, M.B.   +19 more
core   +1 more source

Genetic variation at the apolipoprotein B gene and associations with coronary heart disease and its factors. [PDF]

, 1996
PhDCoronary heart disease (CED) is the major cause of mortality in Western societies. The main risk factors are plasma lipoprotein concentrations, smoking, blood pressure and family history.
Rajput-Williams, Jayshri
core   +4 more sources

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen, Hageman, Jurre, Herrema, H.J., Folkert Kuipers, Hageman, J., Kuipers, Folkert, Herrema, Hilde, Hilde Herrema, Kuipers, Folkert; id_orcid, Groen, A.K., Kuipers, F., Groen, Albert K., Jurre Hageman   +12 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

The effect of oligomeric procyanidins on endothelial function and cholesterol homeostasis [PDF]

, 2012
PhDOligomeric procyanidins (OPC) are naturally occurring dietary substances, which studies suggest can protect against cardiovascular disease. To explore this further a double-blind randomised controlled crossover trial, EPICURE (Evaluation of high ...
Rull, Gurvinder Kaur
core   +4 more sources