Results 51 to 60 of about 1,253,621 (308)

Added predictive value of high-throughput molecular data to clinical data, and its validation [PDF]

, 2010
Hundreds of ''molecular signatures'' have been proposed in the literature to predict patient outcome in clinical settings from high-dimensional data, many of which eventually failed to get validated. Validation of such molecular research findings is thus
Sauerbrei, Willi, Boulesteix, Anne-Laure
core   +1 more source

Domain Adaptation Principal Component Analysis: Base Linear Method for Learning with Out-of-Distribution Data

Entropy, 2022
Domain adaptation is a popular paradigm in modern machine learning which aims at tackling the problem of divergence (or shift) between the labeled training and validation datasets (source domain) and a potentially large unlabeled dataset (target domain).
Evgeny M. Mirkes, Jonathan Bac, Aziz Fouché, Sergey V. Stasenko, Andrei Zinovyev, Alexander N. Gorban   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Low- and High-Dimensional Stock Price Data

, 2017
The data files contain seven low-dimensional financial research data (in .txt format) and two high-dimensional daily stock prices data (in .csv format).
Pun, C (via Mendeley Data)
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Low- and High-Dimensional Asset Prices Data

, 2017
The data files contain seven low-dimensional financial research data (in .txt format) and four high-dimensional daily stock prices data (in .csv format).
Pun, C (via Mendeley Data)
core   +1 more source

GAMLSS for high-dimensional data – a flexible approach based on boosting [PDF]

, 2010
Generalized additive models for location, scale and shape (GAMLSS) are a popular semi-parametric modelling approach that, in contrast to conventional GAMs, regress not only the expected mean but every distribution parameter (e.g.
Mayr, Andreas, Kneib, Thomas, Fenske, Nora, Hofner, Benjamin, Schmid, Matthias   +4 more
core   +1 more source

Factors associated with non-participation of preterm infants at two and five years in a large population-based French healthcare network

BMC Pediatrics
Background Although recommended for the early identification and intervention for developmental impairments, monitoring of preterm infants over several years is hampered by loss of follow-up that inevitably occurs.
Lucas Anzelin, Matthieu Hanf, Laurence Desplanques, Michèle Granier, Laurence Leloup, Alexandre Lapillonne, Véronique Pierrat, Sylvie Escolano, Pascale Tubert-Bitter, Anne C.M. Thiébaut   +9 more
doaj   +1 more source

Dating the break in high-dimensional data

Bernoulli, 2023
This paper is concerned with estimation and inference for the location of a change point in the mean of independent high-dimensional data. Our change point location estimator maximizes a new U-statistic based objective function, and its convergence rate and asymptotic distribution after suitable centering and normalization are obtained under mild ...
Wang, Runmin, Shao, Xiaofeng
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source