Results 101 to 110 of about 407,551 (288)
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics [PDF]
, 2013 Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Here we describe red, single-wavelength GECIs, RCaMPs, engineered from circular permutation of the thermostable red fluorescent protein mRuby.
Looger, Loren L +97 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
High Dynamic Range Images Using Exposure Metering [PDF]
, 2007 在真實的世界裡，景色的亮度差異是非常大的。我們人眼可以同時觀察到很暗及很亮的影像，也就是人眼能適應較大的亮度差異；然而，現在的相機因為裝置結構上的限制，因此無法取得較大的動態範圍影像。所以我們的研究致力於如何取得高動態範圍的影像。 有學者提出利用不同曝光時間來重建出高動態範圍影像的方法。因此我們延伸他們的方法，提出了如何選擇曝光比較好的照片來建立高動態影像的照片。我們的方法主要是量測影像的曝光亮度，然後決定這張照片是否適合我們。使用我們的方法除了能減少時間來重建取得高動態範圍影像外 ...
Chen, Kun-Yi, 陳坤毅
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Portable widefield fundus camera with high dynamic range imaging capability. [PDF]
Biomed Opt Express, 2023 Rossi A +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Enhancement in dynamic range for dual-rotating retarder Mueller matrix polarimetry
Journal of Innovative Optical Health SciencesMueller matrix polarimetry (MMP) has been proven to be a powerful tool for characterizing the microstructural features of biological samples in biomedical research and clinical diagnostics.
Jiongying Lv +4 more
doaj +1 more source
177 dB Linear Dynamic Range Pixels of Interest DSLR CAOS Camera
IEEE Photonics Journal, 2019 For the first time, demonstrated is an extreme linear Dynamic Range (DR) Pixels of Interest (POI) [i.e., Coded Access Optical Sensor (CAOS)] Digital Single Lens Reflex (DSLR) camera design that engages three different types of photosensors within one ...
Nabeel A. Riza, Mohsin A. Mazhar
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source