Results 201 to 210 of about 1,974,678 (268)

High-Efficiency Analytical Protein A Columns for High Sensitivity Monoclonal Antibody Titer Analysis. [PDF]

Anal Chem
Muriithi B, Gritti F, Gilar M, Sarisozen Y, Lauber M, Wyndham K.   +5 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Citric acid-functionalized graphene oxide membranes with enhanced stability and permeability for high-efficiency separation. [PDF]

iScience
Shi T, Xie Z, Mo X, Guo J, Wu F, Xu H, Wang X.   +6 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Systematic Optimization of 293T Cell Electroporation: Balancing High-Efficiency Gene Delivery with Cell Viability

Zhang M, Li M, Zhang D, Yin Q, Yu Z, Gai Z, Wang J, Zhang N, Chen F, Zhao Q, Zhang Z, Yan B.   +11 more
europepmc   +1 more source

Construction and Diversification of Natural Product Biosynthetic Gene Clusters at High Efficiency and Accuracy. [PDF]

ACS Synth Biol
Bai C, Bayona LM, van Wezel GP.
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Optimization of blasting for high-efficiency and low-damage drivage of large-section production drifts in block caving. [PDF]

Sci Rep
Yan S, Jian X, Li X, Feng X, Li G.
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

High efficiency pathway for lower limb orthopedic surgery: A matched historic cohort study. [PDF]

World J Orthop
Lin C, Nagdev T, Zhu DA, Nair GS, Cheng S, Kumar K.   +5 more
europepmc   +1 more source